Clinical Analysis For Amyloidosis Cardiomyopathy

Objective:To improve the understanding of amyloidosis cardiomyopathy by analyzing its clinical features.Methods:Study population(10 patients) was selected from 1st Affiliated Hospital of Zhejiang University during 2010 to 2015 (mean age 59.7 years old). Retrospective analysis of the clinical characteristics, electrocardiogram Echocardiography, laboratory tests, diagnostic methods, courses of treatment and prognosis of amyloidosis cardiomyopathy.Results:Among the 10 cases of amyloidosis cardiomyopathy(8males and 2 females),3 patients had diagnosis of primary amyloidosis cardiomyopathy, while 7 patients had diagnosis of multiple myeloma with amyloidosis cardiomyopathy,.Progressing heart failure was observed in all these patients, The last patient was highly suspicious for amyloidosis cardiomyopathy.Electrocardiogram(ECG)showed that 4 patients were low voltage in the limb leads, and 4 patients had abnormal Q wave,2 patients manifested as left or right bundle branch block.Echocardiography manifested that 9 patients were possessed with left ventricular hypertrophy as well as weakness of the wall motion in diastole and systole,6 patients had pericardial effusion. As for serological outcomes,8 patients had elevated Troponin I and NT-PROBNP.Among the 10 patients,1 patient is still alive and under follow-up due to his short time of history. The other 9 patients died.Conclusion:The patients with amyloidosis cardiomyopathy manifested predominantly as progressing heart failure with poor prognosis, low voltage on limb leads and abnormal Q Wave can be found on their electrocardiogram.Their echocardiography may recommend diffuse hypertrophy of left ventricle,which may contribute to differential diagnosis from other types of cardiomyopathy.