The Clinical Research Of Shenmai Injection On Hemodynamic On Patients With Septic Shock

ObjectiveTo compare the hemodynamic and oxygen metabolic changes and to explore the potential influence in patients with the existing yang weak septic shock (septic shock) before and after intravenous drip Shenmai Injection.MethodsSeptic shock diagnosis criteria is "Surviving Sepsis Campaign: International Guidelines for Management of Severe Sepsis and Septic Shock: 2012" and the "traditional Chinese medicine clinical practice the term" issued by the National Bureau of Technical Supervision (national standard GB/T16751-1997). In March to December 2015,40 cases with yang weak septic shock after received VolumeView duct catheterization and standard western medince therapy were randomly enrolled to case group (n=20) and control group (n=20), case group patients received intravenous drip Shenfu Injection. Clinical status in 30min,2h,4h,6h,24h,48h,76h before and after intravenous drips in case group and the same time points in control group were observed. The evaluations were:parameters of left ventricular end-diastolic volume include intrathoracic blood volume (ITBV) and global end-diastolic volume (GEDV); parameters of right ventricular afterload include SVRI and MAP; parameters of myocardial contractility include CI and CEF;Pulmonary parameters include EVLWI and PVPI; oxygen metabolic parameters include central venous oxygen saturation (ScvO2), blood lactic acid, and PCT for the septic indicator. All data were collected with Microsoft Excel and analyses in SPSS 19.0. P values were calculated by the t test for quantitative variables or Chi-square test for categorical ones in two groups, while variances between and within groups using by One-way ANOVA.ResultsCI, GEF, MAP, ScvO2 and SVRI were escalated while Lac, PCT, ELWI and PVPI were dropped after treatments in two groups (P<0.05), while there was no significance in ITBI and GEDI. There were significant differences of between-group variation in GEF(6h、24h、48h、72h), MAP (6h、24h、48h、72h), Lac (6h、24h、48h、72h), ELWI(4h、6h、24h、48h、72h) and PVPI (0.5h、2h、 4h、6h、24h、48h、72h) (all P<0.05).ConclusionsIntravenous driped Shenmai Injection might strengthen myocardial contractility, ameliorate tissue hypoxia, improve and stabilize the body circulation, but less effective in the capillary permeability and the pulmonary circulation in the case group. Intravenous driped Shenmai Injection might benefit Yang weak patients with septic shock.