Bitter Particles Parker Lotion Experimental Research For The Traetment Of Anorectal And Postoperative Pain

Objective:By studying parkinson bitter lotion particles in anorectal anal Pain efficacy, and the analgesic effect of bitter cedar particles lotion, skin effect and the principle of security research, Provide scientific basis for promotion in clinical.Methods:Randomized controlled method to observe the efficacy of bitter cedar particles lotion for treating pain. The rats were randomly divided into five groups, namely the control group, the control group, bitter cedar particles lotion large, medium and small dose group. (1) foot rat hot plate, after the model is successful, the last smear of drugs after the first 30 minutes, 60 minutes and 90 minutes, and by statistical rat licking time on the hot plate to compare the analgesic effect of the drug group; (2) drug injection writhing, after modeling were injected 0.7% acetic acid solution in the peritoneal cavity of rats, record the number of rats writhing reactions occur within 15 minutes to compare drugs analgesic effect; (3) ELISA method, rats made anorectal postoperative pain model, in addition to the control group, the other groups were given corresponding drugs incision dressing twice a day,3 days after treatment, the inner canthus blood, serum in each group of rats was measured change in IL-6 and IL-10 content by ELISA; (4) dermal safety studies.Results:Experimental results show that the bitter cedar particles lotion large dose group, middle dose (100% and 50%) can significantly increase the rat plantar pain perception threshold (P<0.05 or P<0.01), can also inhibit ice rat writhing reaction phenomena caused by acetic acid (P<0.05); bitter particles Bai high dose group, middle dose (100% and 50%) make anorectal postoperative pain model in the rat serum induced pain substance interleukin-6 (IL-6) were significantly lower analgesic substance interleukin-10 (IL-10) levels increased(P<0.05); through the skin safety of the experimental results can be seen, bitter cedar particles wash agent is administered transdermally, no swelling and itching and other reactions.Conclusion:Bai Granules bitter lotion for anorectal anal pain have the exact effect, the effect is stronger than the control group; bitter cedar particles lotion for topical administration, analgesic effect, bitter cedar particles lotion can make serum IL-6 reduce the content of IL-10 increased; bitter cedar particles in the skin lotion for topical administration, without any adverse reaction, high security.