| Objective To summarize the adult epstein-barr virus infection in patients with clinical features, laboratory examination, characteristics of T cell subgroup, assess adult EBV infection of humoral and cellular immune function. Methods Retrospective analysis clinical data and laboratory test adults hospitalized with EBV infection from august 1990 to May 2015. Results The EBV infection,294 cases of patients with 75 cases death and 219 survivals. With fever in 196 cases (64.62%), upper respiratory tract infection in 128 cases (43.54%); the EBV DNA loads and EA-IgG of the death group are higher than the survival group with statistically significant difference; Laboratory examination with the WBC count, lymphocyte count, neutrophil count, platelet count in death group were significantly lower than the survival group with statistically difference was significant (P< 0.05), the index of blood clotting such as Fbg, PT, APTT, TT are extended in live group than not cured with statistical significance (P< 0.05), the rest indicators such as ferritin, C3, PA, LDH had also significant statistical differences between the two groups; T cell subgroup analysis, compared with survival group, the WBC count is lower in the unsurvival group (4216.16 ± 2468.18,2468.18± 3632.61, P= 0.007), the CD4/CD8 ratio (2.03±2.21) in unhealed group was obviously higher than that of survival group (1.12±0.77) and there is statistically significant (P= 0.006). Patients in multi-system involvement group with total number of WBC, LY%, LY#, B#, T#, CD4+T cell#, CD8+T cells and CD4+CD28+T cells#, CD8+CD28+T cells, CD38+T8# were significantly higher than that of single system involved, and the difference was statistically significant (P< 0.05). Conclusion EB virus infection in adult often with complex and varied clinical manifestations, when combined immunosuppression risk of infection is higher. Joint detection of DNA and virus antibodies is helpful to early diagnosis, T cell subsets in the assess and analysis immune disorders and prognosis of adult epstein-barr virus infection has certain clinical significance. |
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