Assessment Of Left Ventricular Dysfunction In Apical Hypertrophic Cardiomyopathy By Mitral Valve Annulus Motion Parameters

Objectives Use echocardiographic tissue doppler technology(DTI) to measure mitral valve annulus motion paramaters,to assess the left ventricular dysfunction in apical hypertrophic cardiomyopathy.Methods Select 43 patient with apical hypertrophic cardiomyopathy(AHCM group),30 patients with hypertension(HBP group)and 30 healthy control(NC group).Routine 12-lead electrocardiogram and echocardiography were used to measure left ventricular ejection fraction(LVEF),trans mitral diastolic inflow velocties(E,A),mitral annular systolic,early diastolic velocities(Sa,Ea),E/Ea,isovolumic relaxation time(IVRT).Results There was no significant difference in LVEF among AHCM group,HBP group and NC group(p>0.05). There was no significant difference in Sa among HBP group and NC group,HBP group and AHCM group(p>0.05),but Sa in AHCM group was lower than NC group(p<0.05).Ea in HBP group was significantly lower than NC group(p<0.05), Ea in AHCM group was lower than HBP group(p<0.05). Compared with NC group,E/Ea was significantly increased in HBP group(p<0.05),E/Ea in AHCM group was higher than HBP group(p<0.05).IVRT in AHCM group and HBP group were both higher than NC group(p<0.05), IVRT in AHCM group was significantly higher than HBP group(p<0.05). Apex of thickness is negatively correlated with Ea,Sa(p<0.05),and is positively correlated with E/Ea,IVRT(p<0.05).Conclusions 1.The mitral valve annulus motion parameters can be joint used in assessment of left ventricular diastolic function in AHCM;2. To a certain extent,Ea,E/Ea,IVRT can reflect the change of diastolic function.The thicker the apex,the worse the diastolic function, Ea is lower,E/Ea is higher,IVRT is higher;3.Sa reflects systolic function,is more sensitive in evaluating left ventricular systolic function changes than LVEF,speculate existing of decreased systolic function before LVEF change.