Clinical Observation Of Radioactive Dry Eye Radiotherapy Of Nasopharyngeal Carcinoma

Objective:To study the radioactivity of dry eye in patients with nasopharyngeal carcinoma occurrence and age of patients, radiotherapy dose and time, treatment of the correlation.Methods:male patients with nasopharyngeal carcinoma who were aged from 20 to 60 years old in our department were selected. Respectively before radiotherapy, after radiotherapy for the first time, for the fifth time after radiotherapy, after the radiotherapy, the 15th after radiotherapy, the 20 times after radiotherapy, the 25th after radiotherapy, the 30th after radiotherapy, according to CTCAE (commonly used drug toxicity criteria V3.0) dry eye syndrome classification standard classification of dry eye patients that; at the same time through the tear secretion assay, measured around on both sides of the lacrimal gland secretion function value. And through the VARIAN system to obtain the treatment, through the Eclipse program system to obtain the lacrimal gland volume, the dose according to the value of.Results:a total of 34 patients with a total of 68 eyes, left and right sides of lacrimal gland volume are in line with the normal distribution, around on both sides of the lacrimal gland volume differences were not statistically significant (p=0.815); 68 lacrimal gland lacrimal gland volume, according to the average dose, the maximum dose, the smallest dose are accord with normal distribution. There is no correlation between the number of tear secretion changes and treatment. At the end of radiotherapy,47 eyes of 68 eyes had I degree of dry eye symptoms, accounting for 69.1%.,21 eyes did not appear symptoms, accounting for 30.9%. Correlation between dry eye and lacrimal gland volume 8 radioactive tear gland was not statistically significant. The number of radioactive xerophthalmia and radiotherapy is associated, with the increase in the number of radiotherapy, radioactive xerophthalmia probability also increases. Radioactive dry eye and the patient’s age is associated, in different age groups and whether there is radioactive dry eye there was statistically significant difference. The 41-50 years old group appear dry eye maximum likelihood (53.2%); followed by 31 to 40 years old group (21.3%); again is 20 to 30 years old group (17.0%); 51 to 60 years old at least dry eye (8.5%).68 tear gland radioactive dry eye with irradiated dose, there is a correlation between the mean maximum dose and minimum dose.68 lacrimal gland radioactive dry eye and irradiation is associated risk of radioactive dry eye:the emergence of the five field IMRT: 5-field IMRT>7 IMRT> 9 IMRT.68 tear gland radioactive dry eye, treatment, average dose of radiation modes, age are risk factors.Conclusion:radioactive dry eye and lacrimal gland volume and has nothing to do with the radiation frequency, increase the number of radiotherapy, the probability of radioactive dry eye increased.The average dose of irradiation, treatment, age are risk factors for radioactive dry eye.