The Observation Of The Clinical Curative Effect Of Baihegujin Decoction Uniting Sodium Hyaluronate Eye Drops For The Treatment Of Dry Eye With Lung Yin Deficiency

ObjectiveTo observe the clinical curative effect of Baihegujin decoction uniting sodium hyaluronate eye drops in the treatment of dry eye with lung Yin deficiency.Methods200 cases (400 eyes) in patients with dry eye, according to random number table was divided into the treatment group 100 cases (200 eyes) and the control group 100 cases (200 eyes). The treatment group used baihegujin decoction combined with treatment of sodium hyaluronate eye drops. Baihegujin decoctions were provided by the xiamen hospital pharmacy.They were taken orally twice a day, and one package with 150 ml. The treatment group had continuous treatment for 4 weeks as a course. At the same time, in the treatment group, the sodium hyaluronate eye drops which maked by Qilu Pharmaceutical Co, Ltd. were instilled into two eyes thrice daily, one drop every time. The treatment course was four weeks. For another,the control group was given to sodium hyaluronate eye drops, the usage and dosage completely the same with the treatment group.Two groups had an evaluation respectively before and after one course of treatment,with reference to the Chinese medicine new medicine clinical research guiding principles of TCM symptoms and signs scores. It included comprehensive analyzer which used German keratograph ocular surface evaluation-rupture time (break-up time of tear film, BUT), height of the river of tears (tear meniscus height, TMH), envy analysis (redness scan,R-scan). Statistical software SPSS 18.0 was used for statistical analysis of the data.Results:1.The study included 200 patients (400 eyes),8 cases were shed, and the shedding rate was 4%;2.There was no statistical difference in the collecting 192 cases (384 eyes) of the proportion of men and women, ages, testing data and statistical analysis of TCM symptoms and signs scores (P>0.05). There were comparable (see table 2-1,2-2);3. Of symptoms and signs of traditional Chinese medicine after scoring statistics, we found that in the treatment group,26 cases excellence,54 cases utility and 14 cases nullity. The show the efficiency of 27.1%,effective rate was 55.2%, total effective rate was 82.3%; in the control group,12 cases excellence,39 cases utility and 45 cases nullity.The show the efficiency of 12.5%, effective rate was 40.6%, total effective rate was 46.9%. After statistics analysis, two groups on the effective, efficient, total effective rate were statistically significant(P<0.05),the treatment group curative effect is better than the control group(see table 2-3);4. BUT, TMH, R-scan treatment curative effect comparison of data with median (quartile) on the lower quartile-M (P25-P75) Interquartile range said (see table 2-2):BUT:After one course of treatment, the treatment group was 9.46(7.16-11.85)s and 6.40(4.36-7.84)s in the control group.The comparative differences between groups was with statistical significance(.P<0.05).And the curative effect of the treatment group is superior to the control group (See appendix C,Figure 2,Figure 3,Figure 4,Figure 5).TMH:After one course of treatment, the treatment group was 0.20(0.18-0.22)mm and the control group of 0.16(0.13-0.20)mm. The comparative differences between groups was with statistical significance (.P<0.05).And the curative effect of the treatment group was better than the control group (See appendix C,Figure 6,Figure 7,Figure 8,Figure 9).R-scan:After one course of treatment, the treatment group was 0.8(0.6-1.0) and 1.0(0.8-1.2) in the control group. The comparative differences between groups were with statistical significance (P<0.05). In other words, the curative effect of the treatment group was over the control group (See appendix C,Figure 10,Figure 11, Figure 12,Figure 13).5. During the treatment, two groups had no significant adverse drug reactions.Conclusion:1. It’s effective of Baihegujin decoction uniting sodium hyaluronate eye drops for the treatment of dry eye with lung Yin deficiency.2. The effect of Baihegujin decoction uniting sodium hyaluronate eye drops for the treatment of dry eye with lung Yin deficiency is superior to the simple use of sodium hyaluronate eye drops.