Comparison Of Clinical Effect Between Laparoscopic Versus Open Distal Pancreatectomy

Objects Most reports of LDP were case analysis at present. And clinical comparative studys with abundant clinical data were deficient. In this study. We compared the possible differences of clinical effect between laparoscopic versus open distal pancreatectomy, purpose to investigate the feasibility and safety of LDP compare with ODP, As well as the malignant tumor treatment effect and adaptability, providing the basis for clinical treatment.Method A total of 101 patients, admitted to the general surgery department of Qilu hospital from Jan.2010 to Jun.2015, were enrolled and divided into LDP and ODP group,Age,gender, lesion tumor diameter, tumor pathological feature, bleeding loss during operation, operation time, and spleen-preserving, were compared betweew LDP and early ODP group, recovery condition post after operation (time of anal exsufflation,time of start eating, Furthermore hospital stay, complications post operation (abdominal infection,incision infection, pulmonary infection, pleural effusion, incision bleeding,intraperitoneal hemorrhage, pancreatic fistula) were also compared. Data were analyzed using SPSS20.0 statistical software. For measurement datas, average were expressed by mean+/-standard deviation,t test was used to compare mean of two groups; For count data, chi square or Fisher’s exact probability test were used.A P value of <0.05 was considered as statistically significant.Results No statistically significant difference of age,gender, tumor diameter and the history of epigastric operation was found between LDP and ODP group (P>0.05); Compare with ODP group, the average bleeding loss during operation in LDP was less (LDP 251.85±192.65mL, ODP 355.80±319.13mL, (P<0.05) The average operating time in LDP group was shorter than that in ODP group (LDP 212.95±79.46min, ODP 263.38±89.99min, (P<0.05; No statistical significant of spleen-preserving rate was found between LDP and ODP group (LDP61.29%,ODP45.71%, P>0.05); Average operation time in ODP group was longer than that in LDP group (ODP19.60±11.98d, LDP 14.83±6.43d, P<0.05), Compare with ODP group,time of anal exsufflation (LDP2.67±0.44 d, ODP3.40±1.14 d,P<0.05)and starting eating (LDP3.09±1.37 d, ODP4.34±1.81d,P< 0.05)in LDP were shoter; No statistically significant difference of complications rates post operation (intraabdominal infection,incision infection, pulmonary infection, pleural effusion,incision bleeding,intraperitoneal hemorrhage, pancreatic fistula) was found between LDP and ODP group (P> 0.05).Conclusion LDP is safe and feasible with some advantages of bleeding loss, time of operation,shorter operation time, and shorter time of anal exsufflation and starting eating, no insufficiency was seen in malignant tumor treatment. It can be promoted and applied after the support of more data and clinical exploration.