| Objective By Using the method of Shengmai Injection in acupoint injection combined with auricular-plaster therapy to treat impaired glucose regulation, through the changes of each index were observed before and after treatment, objectively evaluated the curative effect of the method, preliminarily discuss the intervention mechanism of using Shengmai Injection in acupoint injection combined with Auricular Pressure on the treatment of impaired glucose regulation.Methods According to the inclusion criteria,60 patients with impaired glucose regulation (IGR) were randomly divided into two groups:treatment group and control group,30 cases in each group. All subjects were given diabetes relate-d knowledge education before entering the group. The control group only treat-ed with lifestyle intervention program; treatment group received Shengmai Inje-ction in acupoint injection and auricular-plaster therapy on the basis of the co-ntrol group, acupoints as follows:body points:①Yishu(EX-B3), Pishu(BL20), Zhongwan(RN12), Zusanli(ST36);②Shenshu(BL23), Ganshu(BL18),Sanyinjiao (SP6), Qihai(CV6);Ear points:lung, spleen, liver, kidney, pancreas and biliary, endocrine. Body acupoints adopt Shengmai Injection in acupoint injection, choo-se one group of acupoints every time, use two body point groups alternately; ear points use sterile Semen vaccariae seed for ear pressure, every 2 days for one packet, two ears alternately. Teatment conducts 10 days for a course,3 co-urses total,5 days between each course.By observating blood glucose, insulin, blood lipid, body mass index (BMI), waist hip ratio (WHR) and glycosylated hemoglobin (HbAlc) before and after treatment, calculates the beta cell functi-on index of OGTT(HBCI), insulin resistance index (HOMA-IR), and early insul-in secretion index (Δ30/ΔG30). Meanwhile, observes changes of TCM clinic-al symptom score index and objectively evaluates the clinical efficacy and saf-ety of using Shengmai Injection in acupoint injection combined with auricular-p-laster therapy on the treatment of IGR.Results(1) After treatment, the total effective rate of the treatment group was 80%, and the control group was 33.3%. The difference of curative effect of two groups after treatment was statistically significant (P< 0.05), the results showed that:the treatment group was better than the control group.(2) After treatment, FPG and 2HPG decreased, the difference was statistically significant (P< 0.05); FPG,2HPG of control group slightly decreased, the difference was not statistically significant (P> 0.05). By rank-sum test, differences of FPG and 2HPG between two groups were statistically significant (P<0.05).The results suggested that the treatment group in the improvement of FPG and 2HPG was better than the control group.(3) After treatment, the insulin resistance index (HOMA-IR) of treatment group decreased significantly compared with before treatment, the difference was statistically significant (P< 0.05); HOMA-IR of control group was slightly decreased compared with before treatment; the difference was not statistically significant (P> 0.05). After treatment, the difference of HOMA-IR between the two groups was statistically significant (P< 0.05). The results showed that the treatment group was superior to the control group in improving insulin resistance.(4) After treatment, HBCI after HOMA-IR correction (HBCI/IR) and insulin early secretion index (AI30/AG30) of treatment group were increased compared with before treatment, the difference was statistically significant (P< 0.05); HBCI/IR and AI30/AG30 of control group were slightly increased, the differences were no statistical significance (P> 0.05). After rank-sum test and t test, differences of HBCI/IR, ΔI30/ΔG30 between the two groups was statistically significant (P< 0.05). Results:the treatment group in improving the basis of islet beta cell secretion function and load secretion function was better than the control group.(5) After treatment, HbA1C of treatment group decreased, the difference was statistically significant (P< 0.05);HbA1C of control group slightly decreased, the difference was not statistically significant(P>0.05).T test shows the difference of HbA1C between two groups was statistically significant(P<0.05). The results indicated:the treatment group in the improvement of HbA1C was better than the control group.(6) After treatment,BMI,WHR,TG,TC of treatment group were decreased compared with those before treatment and the difference was statistically significant(P<0.05);BMI, WHR of control group were decreased compared with those before treatment, the difference was statistically significant(P< 0.05); TC, TG of control group were slightly decreased compared with those before treatment, the difference was not statistically significant(P> 0.05); after treatment HDL-C in both groups were slightly increased, and differences between pre-treatment and after treatment were statistically significant(P< 0.05), after treatment, the difference of HDL-C in two groups was not statistically significant(P> 0.05). By t test, differences of BMI, WHR, TG, TC of two groups were statistically significant(P< 0.05). Results: in treatment group, the improvement in TC, TG, BMI and WHR were better than control group. Both groups were no significant difference in improving the curative effect of high density lipoprotein cholesterol (HDL-C).(7) After treatment, the clinical symptom scores of TCM in treatment group decreased compared with pre-treatment, the difference was statistically significant (P < 0.05); the control group was decreased compared with pre-treatment, the difference was statistically significant (P< 0.05). After t test, the difference of TCM clinical syndrome between two groups was statistically significant (P< 0.05). The results showed that the treatment group was better than the control group in improving the clinical symptoms of TCM.Conclusions1 In this research, the treatment of Shengmai Injection in acupoint injection combined with auricular-plaster therapy can effectively reduce the FPG,2hPG, HbA1C.2 Shengmai Injection in acupoint injection combined with auricular-plaster therapy maybe can effectively improve the pathological basis of IGR, namely HOMA-IR, HBCI.3 Shengmai Injection in acupoint injection combined with auricular-plaster therapy maybe can be effective in the treatment of IGR risk factors (TC, TG, BMI, and WHR).4 The selection of the treatment method is safe and effective, and can be used for clinical use. |
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