Revelent Research Of Pre-eclampsia And Hypothyroidism During Pregnancy

Background Pregnancy-induced hypertension is one familiar disease in obstetrics,Pregnancy combined with thyroid disease which caused adverse effect on mothers’ health especially on fetus’ development, become more and more common. Previously,most research mainly focused on the relationship of pregnancy combined with hypothyroidism and gestational diabetes(GDM),There are few studies investigate the relationship of abnormal thyroid function and pre-eclampsia.Objectives This study employed pregnant women with mild or severe pre-eclampsia, and healthy pregnant women, aimed to analysis the characteristic of thyroid change in pregnant women with pre-eclampsia, and investigate the relationship of thyroid dysfunction with occurence, development of pre-eclampsia, and finally proposed clinical reference for the prevention and treatment of the pregnant women with pre-eclampsia combines with thyroid dysfunctionThis study chose the patients based on the eighth Internal Medicine. Clinical data of mild pre-eclampsia pregnant women(n=160), severe pre-eclampsia pregnant women(n=160) from inpatient and normal pregnant women(n=160) from outpatient were strictly collected according to the inclusive criteria from Sep 2013 to Sep 2015 in the Third Affiliate Hospital of Luohe Medical College and Second People’s Hospitlal of Luohe. Age was from 22 to 35 years old, and gestational week was 25 ~35 weeks. Venous blood were sampled with vacuum blood tube and placed for 30 min,followed by centrifuge at the speed of 2000 rpm for 10 min. Then serum was seperated and subpackaged in-70 ℃ refrigerator. The free triiodothyronine, free thyroxine, and thyroid stimulating hormone were tested by chemiluminescence method; aspartate aminotransferase, alanine transaminase and cystatin C were tested by biochemical methods. The tests were carried out every four month.Data are expressed as mean ± standard deviation( c ±s), SPSS 18.0 software is used to analysis the variance among different groups, and P<0.05 is considered statistically significant.MethodsResults1. For the three groups pregnant women, as pre-eclampsia become severer, both serum FT3 and FT4 levels were decreased, while TSH showed opposite trend, with significantly difference(P<0.05), and the positive ratio both TPO-Ab and ATG show significant increase(P<0.05).2. Both serum AST and Cys C level were significantly higher in pregnant women with mild or severe pre-eclampsia combined with hypothyroidism and that in pregnant women without hypothyroidism(P<0.05).3. The ratio of adverse perinatal outcome was significantly higher in pregnant women with mild or severe pre-eclampsia combined with hypothyroidism and that in pregnant women without hypothyroidism(P<0.05).4. One month after delivery, pregnant women with mild pre-eclampsia combined with hypothyroidism showed increase of serum FT3, FT4 without significant difference and decrease of serum TSH with significant difference(P<0.05). Pregnant women with severe pre-eclampsia combined with hypothyroidism showed increase of serum FT3 and decrease of serum TSH with significant differences(P<0.05).Conclusions1. Pregnant women with mild or severe pre-eclampsia combined with hypothyroidism have severer liver damage and increased adverse perinatal outcome that that without hypothyroidism.2. Monitoring of serum thyroid hormone levels of pregnant women with pre-eclampsia helps to earlier diagnose and treat pregnant women with hypothyroidism and sub-clinical hypothyroidism, and decrease adverse outcome of perinatal infant.