Analysis Of Preoperative Blood Lipid Level And Prognosis Of Resectable Non-Small Cell Lung Cancer

Background:Non-small cell lung cancer (NSCLC), which accounts for 85% of the primary bronchogenic carcinomas, has the highest mortality rate of malignant tumors in the world. In the progression of tumor, the metabolism of body will change accordingly. The main biological function of lipid in the body is storing energy and the formation of the main components of cell membrane and important signal molecules. Therefore, there is important clinical significance for the diagnosis and prognosis of lung cancer in the research on lipid levels in patients with lung cancer. The role of lipid metabolism in cancer development has not been fully explored, and the prognostic role of HDL-C(high-density lipoprotein cholesterol), LDL-C(low density lipoprotein cholesterol), TC(cholesterol) and TG(triglyceride) is not completely defined. In our research, we explored the correlation of preoperative blood lipid level and prognosis of resectable NSCLC.Objective:The aim of our study was to investigate the association between preoperative blood lipid levels and the prognosis in resectable NSCLC patients. We hoped to find a new direction for the treatment of lung cancer.Methods:Levels of preoperative blood lipid concentrations (including HDL-C, LDL-C, TC, and TG) were retrospectively analyzed with resectable NSCLC patients who underwent complete resection (lobectomy and mediastinal lymph node dissection with microscopic examination of margins showing no tumor cells) from January 2009 to December 2010 at Shandong university qilu hospital in this study, totally 165 cases. We Followed up age, gender, smoking history, preoperative serum total TC, preoperative serum total TG, preoperative serum total HDL-C, preoperative serum total LDL-C, pathologic type, differentiation degree, lesion, tumor diameter and pTNM stage in NSCLC patients and their overall survival (OS) and progression-free survival (PFS), then analyzed the association of them. The pTNM stage was based on 2009 IASLC international lung cancer stage (the seventh edition). Preoperative serum TC, HDL-C and LDL-C divided into groups were based on the NCEP ATP III dyslipidemia guideline. We used the chi-square test, Kaplan Meier survival curve, COX proportional hazards model in SPSS 17.0 system to deal with data. There is statistical significance when P value is less than 0.05.Results:165 cases of patients were included in this study, while 115 cases of them (69.3%)were men and the other 50 cases (30.3%) were women. They aged from 35 to 82 years old (60.61 ±9.68). Preoperative serum TC is an independent risk factor of prognosis of resectable NSCLC. The OS(P=0.005) and PFS(P=0.006) of patients with preoperative serum TC concentration over 200 mg/dl are better than these of patients with below 200 mg/dl. Preoperative serum TG, HDL-C, LDL-C have no correlation with prognosis of rersectable NSCLC.Conclusions:Preoperative serum TC level is an independent risk factor of the prognosis of resectable NSCLC, and lower preoperative serum TC level means poor prognosis. The test of blood lipid level could predict the survival time of postoperative NSCLC, which may play an important role in the tumor prognosis.