Application Of Time Specific Multi-phase Dynamic Contrast-enhanced MRI Scanning,semi-quantitative Parameter Analysis In Hepatocellular Carcinoma

Part â…  Application of Time Specific Multi-Phase Dynamic Contrast-Enhanced MRI Scanning in Hepatocellular CarcinomaObjective: To explore the application of time specific multi-phase dynamic contrast-enhanced MRI scanning in the diagnosis of hepatocellular carcinoma.Materials and Methods: 22 patients with the hepatocellular carcinomas were included in our study from the PLA 306 th Hospital from the year 2011 to year 2015. All the lesions were proven by pathology or clinical diagnosis. In all patients, the time specific dynamic contrast-enhanced MRI scanning was performed according to the individual delay time measured by test-bolus method, multi temporal continuous acquisition of a total of 9 series of images were obtained. The signal intensity values of the regions of interest in hepatocellular carcinoma, liver tissue, abdominal aorta,hepatic artery, portal vein and inferior vena cava were measured in the 9 phases.(1) The time-signal intensity curve was drawn and the relative added value of signal intensity in each part were calculated;(2) A comparative study on the relative added value of the signal intensity in each phase of hepatocellular carcinoma and liver tissue;(3) Comparative study on the relative added value of signal intensity in each phase of hepatocellular carcinoma.Results:(1) It can be observed from the time-signal intensity curve of each part that: liver tissue and portal vein arrived at the peak level of signal intensity in the portal venous phase while both gradually decreased in equilibrium phase and delayed phase. The peak value of hepatocellular carcinoma was enhanced in the late arterial phase, then decreased gradually and was lower than liver tissue in the same phase. Also the curve indicated that the liver tissue and portal trunk, hepatic artery and abdominal aorta were at respective synchronous enhancement.(2) Significant signal differences in the middle and late hepatic arterial phase between the hepatocellular carcinoma and liver tissue(P<0.05).(3) There are significant differences in the early and middle arterial phase of hepatocellular carcinoma with the late arterial phase and portal vein phase(P<0.05),while no significant differences in the early, middle, late portal vein phase.Conclusion: Time specific multi-phase dynamic contrast-enhanced MRI scanning according to the individual circulation differences can accurately and objectively obtain the images of each phase, also playing a certain role in the diagnosis of hepatocellular carcinoma.Part Applicationâ…¡ of Semi-Quantitative Dynamic-enhanced MRI and Time-Signal Intensity Curve in Hepatocellular CarcinomaObjective: To explore the application of semi-quantitative dynamic-enhanced MRI and time-signal intensity curve in diagnosis of hepatocellular carcinoma.Materials and Methods: 20 patients with hepatocellular carcinomas that from the PLA 306 th Hospital were included in our study from the year 2011 to year 2015. All cases underwent a total of 9 phases of time specific dynamic-enhanced MRI scanning and all the lesions were proven histopathologically and/or clinically. The time-signal intensity curve was obtained and peak signal enhancement percentage change, enhancement slope and wash-out slope of the regions of interest in hepatocellular carcinoma and liver tissue were measured separately. The shape of time-signal intensity curve was observed and the data of semi-quantitative parameters were compared by statistical methods.Results: The time-signal intensity curves of hepatocellular carcinomas can be expressed as rising quickly in the arterial phase while showing varying degrees of downward trend in later phases. Peak signal enhancement percentage change was(184.46?52.54) in hepatocellular carcinoma and(126.09?46.26) in liver tissue with significant differences(P<0.05). Enhancement slope was(4.74?1.55) in liver tissue and(11.18?5.78) in hepatocellular carcinoma with significant differences(P<0.05). There were no significant differences of wash-out slope that was(0.48?0.25) in hepatocellular carcinoma and(0.38?0.14) in liver tissue(P>0.05).Conclusion: The shape of the time-signal intensity curve can directly reflect the inflow and clearance of contrast medium, and semi-quantitative parameter analysis can indirectly estimate the characteristics of tumor microcirculation, which is helpful for the evaluation of HCC..