Clinical Implications Of Plasma Omentin Levels In Patients With Hyperuricemia

Objective:Discuss the change and clinical significance of omentin in hyperuricemia by comparing the difference of serum omentin level between hyperuricemia and normal subjects. Discuss the need for treatments of asymptomatic hyperuricemia by using dual energy CT.Method:We randomly selected 74 patients (50 with hyperuricemia VS 24 healthy) from department of Pathology of Nanjing General Hospital of Nanjing Military Command between July 2015 and March 2016. All of the hyperuricemia satisfied the diagnostic standard. All of the subjects satisfied the exclusion criteria (without special medical history within 3 months, such as glucocorticoid, antibiotic, or uric-acid-lowering drugs. No hypertension, diabetes mellitus, nephropathy, operation history, hepatopathy, BMI<30Kg/m2). Record the age, height, weight, and blood pressure of the subjects. We had collected all of their serum. Centrifuge the fasting blood, collect serum, and examine FBG, TC, TG, LDL-C, HDL-C, AST, ALT, UA, and FINS. Use enzyme linked immunosorbent assay to determine serum omentin level. Depending on the subjects’ examination intention to give them dual-energy CT examination. Finally,23 subjects with gout received DECT (dual-energy CT) VS 20 with asymptomatic hyperuricemia. We used SPSS software to statistical analysis of the experimental results, analyse the differences in expression levels of omentin and the different positions of tophus.Results:(1) Comparing with the control group, there are no significant differences between hyperuricemia and control group including BMI, FBG, FINS, TC, TG, and LDL-C (P>0.05).(2) Age, TG and UA of gout are all higher than asymptomatic hyperuricemia, but HDL-C is lower (P<0.05). In addition, there are no significant differences between hyperuricemia and control group of BMI, SBP, DBP, FBG, TC, HbA1C and HOMA-IR (P>0.05).(3) The positive rate of tophus in asymptomatic hyperuricemia can reach 70%, while 95.7% in gout.(4)The omentin level of hyperuricemia is significant higher than normal subjects (8.56±7.72 ug/L vs 3.42±2.82 ug/L, P=0.002). Comparing with asymptomatic hyperuricemia, there is no significant difference of omentin level in gout (9.31±8.85 ug/L vs 7.8±6.39 ug/L, P=0.926).(5) Correlation analysis showed the omentin level of hyperuricemia had no relationship with age, BMI, blood pressure, carbohydrate metabolism, lipid metabolism and the level of UA (P>0.05)Conclution:1.0mentin level is much higher in hyperuricemia compare with normal subjects but has no relationship with many biochemical indexs, such as LDL-C、HDL-C、TG、TC and BMI.2. There is no difference of omentin level between asymptomatic hyperuricemic patient and gout.3. The positive rate is much lower in asymptomatic hyperuricemia compare with gout.