The Value Of Liver And Spleen Stiffness Measured For Assessing The Diagnosis And Prognosis Of Portal Hypertension In Liver Cirrhosis Patients

Objective:To investigate the value of liver and spleen stiffness measured by FibroTouch transient elastography for assessing the diagnosis and prognosis of portal hypertension in liver cirrhosis patients by analysising the correlation between liver and spleen stiffness with the imaging parameters of portal hypertension. Methods: A total of 120 cirrhotic patients,who underwent gastroscopy in the Department of infectious disease of First Affiliated Hospital of Xinjiang Medical University during Janury 2014 to January 2016, divided into four groups based on the results of the level of esophageal varices. And 30 healthy controls were enrolled.All the patients and controls were evaluated for spleen and liver stiffness by FibroTouch, abdominal color doppler ultrasonography to record portal vein width,spleen volume,and splenic vein width and the number of platelet. R ceiver operating characteristic(ROC)curves were generated and the areas under the curves(AUCs)were calculated to assess the accuracy ofthe FibroScan liver and spleen stiffness measurements to predict esophageal varices.Pearson’S correlation analysis was used to assess the relationship between clinical features.Results:Liver and spleen stiffness were higher than healthy controls.Liver stiffness was positively correlated with spleen stiffness(P<0.05).Liver and spleen stiffness were positively correlated with esophageal varices,portal vein width,spleen thickness,spleen volume,and.There was no relationship between liver stiffness with splenic vein width,while spleen stiffness were positively correlated with splenic vein width.The correlation of spleen stiffness was higher than that of liver stiffness.Liver and spleen stiffness was also negatively correlated with platelet count. The optimal cut—off level of liver stiffness for prediction of EV and EBV were 17.1(sensitivity:66.2%,specificity:83.7%),while the optimal cut—off level of liver stiffness for prediction of EV and EBV were 50.4(sensitivity:85.7%,specificity:93.0%). Conclusion: Both liver and spleen stiffness measurements correlated with portal hypertension. AS a non-invasive diagnosis method,Both Liver stiffness and Spleen stiffness measured by transient elastography is a valuable parameter for diagnosis and prognosis of portal hypertension in liver cirrhosis patients.