The Clinical Value Of MPV Combined With Hs-CRP And IL-6 In Predicting The Occurrence Of MACE In Patients With Non-reperfusion Acute Myocardial Infarction

Objective: The aim of this study was to evaluate the clinical value of MPV combined with hs-CRP and IL-6 in predicting the occurrence of MACE in patients with non-reperfusion acute myocardial infarction. Methods: A total of 150 consecutive patients with primary acute myocardial infarction who were admitted to the First Affiliated Hospital of Xinjiang Medical University from October 2014 to October 2015 were selected,enrolled cases were divided into two groups based on whether to treat with percutaneous coronary intervention:PCI group(reperfusion group) and non-PCI group(non-reperfusion group),comparing the difference between the two groups of clinical data and laboratory examination.According to the occurrence of major adverse cardiovascular events(MACE),two groups were divided into the MACE group and non-MACE group,further analysised of the differences of MPV,hs-CRP, IL-6 within and between the subgroups,to study the relation between three indices and in-hospital MACE in patients with reperfusion and non-reperfusion acute myocardial infarction.Calculating the area under the ROC curve of MPV,hs-CRP,IL-6 and co-detection of three indices,to evaluate their predictive value in the prognosis of AMI.All patients was followed up for a month after discharge to observe the incidence of MACE and compare the changes of MPV,hs-CRP,IL-6 before and after the treatment. Results: PCI group compared with non-PCI group,there were significant differences among age,BMI,LVEF,MACE,MPV,hs-CRP,IL-6,there were no significant differences in gender,ethnicity,diabetes,hypertension,serum glucose,TC,LDL-C,HDL-C,CK,CK-MB, hs-cTnT, PLT, PDW,PCT and so on.The level of MPV, hs-CRP and IL-6 were compared within and between the two subgroups,the difference was significant.The correlation analysis showed that MPVand hs-CRP, IL-6 was moderately positive correlation.The area under the ROC curve of co-detection of three indices is the largest.With follow-up one month, there was no significant difference in the incidence of MACE between the PCI group and the non-PCI group, the level of three variables have no significant change before and afterthe treatment.Conclusion:MPV combined with hs-CRP,IL-6 detection can improve the predictive value of in-hospital MACE in patients with non-reperfusion acute myocardial infarction...