Synthesis Of Statin Rosuvastatin Derivatives

With the problem of population aging is getting worse and worse, Cardiovascular disease is becoming one of the most dangerous threats to human. By adjusting the level serum lipid, Rosuvastatin Calcium displayed significantly better than other Stations drugs on Pharmacodynamics and Safety. The mechanisms is provents HMG-CoA in the liver, in order to reduced lipoprotein production in the liver and at the same time increased the expression of LDL-cholesterol receptors, Ultimately makes the cholesterol level has been dropped in the plasma, which means it achieve the purpose of prevention of cardiovascular disease. As effective choleste rol-lowering drugs, Rosuvastatin calcium have a very broad market prospects and brilliant.In order to enhance the Pharmacodynamics and Safety of Rosuvastatin, the major task of subject is to change the two chiral hydroxy (3R,5S) on its chiral side chains by chemical synthesis means and modify the methyl on the polarity methanesulfonamide to form UC2171, UC2172, UC2173, UC2174 four derivatives. The synthesis of Rosuvastatin derivatives could give guide to the research of other derivatives of these series of drugs. It has high economic and social value to a certain extent, it could prevents foreign companies monopolize the domestic market.