| Objective:To study the distribution of lipid profiles and its relationship with the different index of obesity among Korean-Chinese students in Yanbian area, so as to provide the reliable information and guidance for the primary schools where carrying out the health care work.Methods:1) BY using a cluster sampling method, a total of 2 011 elementary school students (boys,943; girls,1068) aged 8-12 years old were finally selected in two primary schools and the survey was carried out in June 2010. All of students knew the informed consent. We excluded:① ethnic groups other than Korean-Chinese and Han-Chinese; ② subjects of mixed blood. The information for this study was collected by the standardized questionnaire.2) Physical examination was carried out in the early morning after 12 hour fasting. Using the standard methods, we measured height (cm), weight (kg), waist circumference (WC, cm), total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C).3) Body mass index (BMI, kg/m2), WC and waist-to-height ratio (WHtR) were employed as the obesity indices. 4) Dyslipidemia was defined:(1) According to the percentiles of measurement of lipid profiles among Korean-Chinese students in Yanbian area,①High TC defined as TC≥P90; ②High TG defined as TG≥P90; ③Low HDL-C defined as HDL-C≤ P5; ④High LDL-C defined as LDL-C>P9o. (2) According to NCEP diagnostic criteria for adolescent, ① High TC defined as TC≥5.2 mmol/L;② High TG defined as TG>1.69mmol/L; ③ Low HDL-C defined as HDL-C<0.9 mmol/L;④High LDL-C defined as LDL-C>3.4 mmol/L.5) Data analysis was performed by SPSS 17.0 statistical software. Normal distribution measurement data were examined by t-test and analysis of variance, the numeration data were compared with the Chi-square test; the correlation between lipid profiles and the different index of obesity was analyzed by a simple correlation analysis and partial correlation analysis.Results:1) The level of TC was 3.71±0.64 in boys and that was 3.75±0.63 in girls, and there was not sex difference (t=1.369, P>0.05), and the level of TC of Korean-Chinese students in this area was progressively higher with the increases of age (F=6.310, P<0.05). The level of TG was 1.02±0.51 in boys and that was 1.10±0.50 in girls, and there was sex difference (*=3.653, P<0.01), and the level of TG was progressively higher with the increases of age (F =27.496, P<0.01). The level of HDL-C was 1.48±0.31 in boys and that was 1.43±0.29 in girls, and there was sex difference (t=3.820, P<0.01), and the level of HDL-C was progressively higher with the increases of age (F=23.001, P<0.01). The level of LDL-C was 1.95±0.55 in boys and that was 2.02±0.55 in girls, and there was sex difference (t=2.719, P<0.01), and the level of LDL-C was not progressively higher with the increases of age (F =2.769, P>0.05).2) The P90 of TC was 4.50 in boys and that was 4.59 in girls, and that of TG was 1.59 and 1.66, and that of LDL-C was 2.67 and 2.72, and the P5 of HDL-C was 1.89 and 1.80, respectively, and there was not sex difference for all of them. Compared with the diagnostic criteria of dyslipidemia defined by NCEP, the P90 of TC (4.55/5.2), TG (1.62/1.69) and LDL-C (2.70/3.4) was lower for Korean-Chinese students in this area, and the P5 of HDL-C (1.01/0.9) was higher.3) According to the measurement of lipid profiles among Korean-Chinese students in Yanbian area, the detection rate of high TC was 9.3% in boys and that was 10.8% in girls, and that of high TG was 9.3% and 10.9%, and that of low HDL-C was 5.0% and 5.1%,and that of high LDL-C was 9.4% and 10.6%, respectively, and there was not sex difference for all of them. (2) According to NCEP diagnostic criteria, the detection rate of high TC was 2.8% in boys and that was 2.3% in girls, and that of high TG was 7.6% and 9.8%, and that of low HDL-C was 1.5% and 1.4%, and that of high LDL-C was 1.5% and 1.3%, respectively, and there was not sex difference for all of them.4) The levels of BMI, WC and WHtR were progressively higher with the increases of TC, TG and LDL-C (all P<0.01), and that was progressively higher with the decrease of HDL-C (P<0.01).5) The partial correlate analysis showed that there was a positive correlation between TC and BMI, WC and WHtR, the partial correlate coefficient was 0.071,0.055 and 0.092 (all P<0.05); there was a positive correlation between TG and BMI, WC and WHtR, the partial correlate coefficient was 0.288,0.296 and 0.284 (all P<0.0001); there was a positive correlation between LDL-C and BMI, WC and WHtR, the partial correlate coefficient was 0.184,0.159 and 0.192 (all P<0.0001); there was a negative correlation between HDL-C and BMI, WC and WHtR, the partial correlate coefficient was-0.289,-0.285 and -0.260 (all P<0.0001).Conclusion:1) There was sex difference in distribution of TG, HDL-C and LDL-C, and the levels of TC, TG and HDL-C were progressively higher with the increases of age.2) Compared with the diagnostic criteria of dyslipidemia defined by NCEP, the P90 of TC, TG and LDL-C was lower for Korean-Chinese students in this area, and the P5 of HDL-C was higher. (3) The detection rates of dyslipidemia defined by the percentiles of measurement of lipid profiles among Korean-Chinese students in Yanbian area and NCEP diagnostic criteria are different. It is suggested to select the appropriate lipid profiles reference norm in screening and diagnosis of dyslipidemia for adolescents, and it is important in dyslipidemia-related study.4) The levels of BMI, WC and WHtR were progressively higher with the increases of TC, TG and LDL-C, and that was progressively higher with the decrease of HDL-C.5) There was a significant correlation between lipid profiles and the different indexes of obesity. |
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