A Case-control Study On Related Risk Factors Of Progesterone For Uterine Leiomyomas

Uterine leiomyomas are the most common benign tumor in women of reproductive age,the prevalence of uterine leiomyomas in 40-50 years old woman was found to be 50%.Conventionally, estradiol has been considered the primary stimulus for UL growth,while clinical and basic evidence supports an important correlation between progestins and growth of leiomyomata.It is not fully known yet if there is association between wide use of progesterone, even misuse and incidence of uterine fibroids. In addition, the occurrence of myoma also related to genes,reproduction, feeding and other factors.ObjectiveThis study investigates whether the clinical application of progesterone is safe,and provides a theoretical basis for the effective prevention and control of uterine fibroids.MethodsThis is a Case-Control study with 320 cases as patients with uterine leiomyoma confirmed by The Third Affiliated Hospital of Zhengzhou University as the case group from January 2014 to March 2015, All of the patients in the case group wereproved as uterine leiomyomas pathologically after surgeries. while 320 cases were patients without uterine leiomyoma or healthy volunteers as the control group during the same period,patients in the control group were excluded from uterine fibroids by imaging examinations. 1:1 matched case-control study was used to explore the influential factors for uterine myomas.We entered the results into database and analyzed the materials with univariate or multivariate unconditional logistic regression analysis.ResultsUnivariate logistic regression analysis showed that progesterone use, place of residence, BMI, exposure to cosmetics, consumption of soybean milk and honey,menarchal age, menstrual disorder, history of number of abortions, and use of oral contraceptive, had statistically significant differences between the case and control group. Multivatiate logistic regression analysis indicated that progesterone use,consumption of soybean milk, menarchal age, menstrual disorder and history of number of abortions were related with uterine leiomyoma.ConclusionProgesterone use, consumption of soybean milk, menstrual disorder and history of number of abortions may be the risk factors for uterine leiomyoma while late menarche may be the protective factor for uterine leiomyoma.