Expression And Significance Of IL-6 And NF-κB In Prostate Cancer

Objective To explore the expression of IL-6 and NF-?B in prostate cancer and its relationship with clinicopathological features;Methods To study the expression of IL-6 and NF-?B in 42 cases of prostate cancer and 26 controls of benign prostatic hyperplasia tissue were examined by immunohistochemistry staining, and to investigate the relationship between IL-6, NF-?B and the biological behavior of prostate cancer using SPSS software. All specimens were confirmed by pathological examinations.Results In comparison with those in benign prostatic hyperplasia, the expression of IL-6 and NF-?B in prostate cancer was significantly higher(P<0.05). There was a positive correlation between the expression of IL-6 in prostate cancer and PSA level, the clinical stage and Glesason scores(p<0.05). Likewise, significant association was detected between the expression of NF-?B and PSA level, the clinical stage and lymp hnode metastasis(p<0.05);Conclusions The expression of IL-6 and NF-?B was higher in prostate cancer, and found its relationship with aggressiveness of prostate cancer.