The Value Of Mean Platelet Volume For Us To Predict Risk And Prognosis Among Patients With Acute Coronary Syndrome

Objective1 To verify the value of mean platelet volume for us to diagnose acute coronary syndrome (ACS) and whether different types of acs patients with different MPV value.2 To understand the relationship between mean platelet volume and ACS and find the answer that is higher mean platelet volume resulting in higher risk.3 Find several risk factors for patients who suffered with ACS and make sure that MPV is an independent risk factor for ST-segment elevation in patients with acute coronary syndrome.4 To answer the question that whether MPV is important in predicting risk and short-term prognosis after leaving hospital among patients with ACS.Methods1 All cases of patients with ACS were divided into STE-ACS group and NSTE-ACS group to analyze whether there is a significant difference in MPV values between the two groups.2 All patients were also divided into high-risk group and not high-risk group by the GRACE score when they went into the hospital to analyze the same difference. When they left the hospital they were divided into two groups again by the GRACE score on that time. The difference would also be judged between the subgroups of not high-risk group.3 Risk factors among fasting plasma glucose, age, gender, platelet count, mean platelet volume and LDL-C for ST-segment elevation in patients with ACS would be found by using logistic regression.ResultsThere are 235 patients in this survey. The STE-ACS group has 101 people and the others are in NSTE-ACS group. There is no significance difference between the two groups on gender, fasting plasma glucose or LDL-C, but age (p=0.005), platelet count (p=0.007) and mean platelet volume (p=0.000) are all different between the groups, especially for the mean platelet volume which is much higher in STE-ACS group than the other one. Mean platelet volume of the high-risk group is higher than the not high-risk group when the patients went into hospital (p=0.002), the same result appeard when they left the hospital (p=0.009). However, the MPV between the subgroups of not high-risk group are similar both when the patients went into hospital (p=0.124) and left the hospital (p=0.857). Logistic regression analysis shows that compared to gender (p=0.479), fasting plasma glucose (p=0.746), platelet count(p=), uric acid(p=0.950) andLDL-C(p=0.091), age(p=0.016, OR[95%CI]=1.033[1.006-1.106]) and mean platelet volume(p=0.000, OR[95%CI]=2.857[2.082-3.920]) are independent factors for ST-segment elevation among patients who sufferd with acute coronary syndrome.Conclusion1 Mean platelet volume and acute coronary syndrome are closely related, especially for patients who have ST-segment elevation.2 Mean platelet volume of high-risk patients with ACS are higher than not high-risk ones both when they went into hospital and left hospital and there is no significent difference between low-risk people and middle-risk people at both of the two time points.3 Age and mean platelet volume are independent factors for ST-segment elevation among patients sufferd with ACS.4 Mean platelet volume is useful for us to predict risk and prognosis among patients with acute coronary syndrome.