The Mean Platelet Volume Combined With Grace Score On The Prognosis Of Acute Coronary Syndrome

Background and purpose: The mean platelet volume (mean platelet volumeMPV) is the mean platelet volume, is an important indicator of clinical detection, canjudge the bleeding tendency and bone marrow hematopoietic function change. Inrecent years, studies have shown that MPV is closely related to coronary heart disease,clinically can be as an index for evaluating the prognosis of cardiovascular disease.Studies have shown that increased MPV and shorten the bleeding time and clotting4-dioxane increased plasma concentrations are associated, therefore, MPV can serveas an indicator of platelet function. Boost platelet hormone of the MPV can someadjustment, in addition, growth factor cytokines can also cause such as large size, theproduction of highly active platelets in the bone marrow, so as to increase theconcentration of the such platelets under certain conditions, such as obesity,endothelial dysfunction and myocardial ischemia, etc.). Because the MPV value andthere exists a significant correlation function of platelet activity, at the same time,MPV testing process with the advantages of simple operation, low cost, MPV hasgradually become a stroke, acute myocardial infarction (acute myocardial infarction,AMI) and coronary artery restenosis after angioplasty and other important predictorsof disease and prognosis.Research methods:1) After admission record the patient’s age, gender, heart rate,blood pressure, major adverse cardiovascular events. Whether merger of hypertension,hyperlipidemia, diabetes, and so on and so forth.2) Admitted to hospital after thesecond day early in the morning on an empty stomach (8hours) was collected venousblood, extract the anticoagulant and anticoagulant blood specimens, separation ofserum, plasma two Ependorff tube packing, related index inspection.3) TC, TG, LDL-C, BNP testing should be used in the United States beckman AU5800type fullautomatic biochemical analyzer for testing; MPV, the WBC testing using mindrayBC5800) blood analyzer; Hs-CRP with scattering turbidimetric method adopts thebeckman Array360System equipment.4) GRACE score calculation: based on theobservation of patients admitted to hospital variables: age, heart rate and systolicblood pressure, serum creatinine, Killip classification, ST segment changes, elevated myocardial injury markers, see a doctor without cardiac arrest. According to thevariables of the scores of GRACE score values, we adopt GRACE calculator tocalculate scores. All statistical analysis of SPSS19.0software was used to statisticalanalysis, normal distribution measurement data to mean+/-+s) said, usinganalysis of variance and t test to the standard deviation (2comparison betweenthe two groups of data. Count data comparing the inspection; Multiple linearregression analysis of MPV independent factors, P <0.05for the difference wasstatistically significant.Results: By ROC curve analysis, level of MPV is9.9%or more recent prognosis inpatients with ACS level of MPV <9.9%survival rate decrease (P=0.001); By singlefactor related analysis level of MPV and GRACE score, killip classification, the WBC,hs CRP, BNP, correlation, correlation coefficients were0.411,0.426,0.574,0.535,0.709, P <0.05, differences were statistically significant.Conclusion:1. MPV levels of9.9%or more in patients with ACS recent mortality than levelof MPV <9.9%higher.2. MPV can be used as a prediction of acute coronary syndrome was anindependent predictor of risk of death within30days.3．MPV and GRACE score can improve the prediction of recent risk of death inpatients with ACS.