Studies On Heart Rate Fluctuation Related To Periodic Limb Movement During Sleep In Parkinson Disease

Objective:To analyze the patterns of periodic limb movement related heart rate (HR) change in Parkinson’s disease (PD) patients with periodic limb movement during sleep (PLMS). Methods:Following the design strategy of case-control study, we included the patients diagnosed with PD and PLMS as case samples, and the patients with idiopathic PLMS as control samples. For all the samples, the dynamic monitoring of PLMS was performed using polysomnography (PSG). Limb movement related HR was compared between case and control samples. In detail,20 R-R intervals comprising 5 before the limb movement and 15 after the movement were converted into HR. HR at different time and global HR change patterns were explored in case and control samples individually. And then, the difference of HR and HR amplitude were compared between these two groups. Results:In both case and control groups, HR shown a significant statistical changes before and after the event of limb movement. And at multiple time points including T1-T5 and T12-T19, HR are significantly different between case and control samples. The time of peak of cardiac acceleration in case samples delays one beat than that in control samples. Conclusion:Both PD with PLMS patients and idiopathic PLMS patients, periodic limb movement related HR will follow’increasing-decreasing’change patterns. PD with PLMS patients have smaller amplitude in HR change during cardiac acceleration and de-acceleration stages than that of idiopathic PLMS patients. The time of peak of cardiac acceleration in PD with PLMS patients delays one beat than that in idiopathic PLMS patients.