| Objective: To investigate the value of CT perfusion in the evaluation of tumor vessel growth and neoadjuvant chemotherapy in locally advanced cervical squamous carcinoma to neoadjunt chemotherapy, providing the basis for evaluation tumor angiogenesis in vivo imaging and prediction the sensitivity of neoadjuvant chemotherapy in patients with cervical cancer. Methods: 81 cases of cervical cancer(surgery: 35 cases, neoadjuvant chemotherapy:46 cases) and 20 cases of normal cervical group from January 2013 to June2014 under 128-slice CT perfusion examination. Comparing the differences of CT perfusion parameters between cervical cancer and normal cervical group、the correlation between MVD and CT perfusion parameters、the differences of CT perfusion parameters in VEGF different expression groups and in effective and ineffective group for neoadjuvant chemotherapy.Results:(1) CT perfusion parameters BF、 BV、PMB in cervical cancer was higher than normal cervix group, MTT, TTP were shorter than normal cervix group, the difference between the two groups were statistically significant(P <0.05).(2) CT perfusion parameters BF、 BV、 PMB were positively correlated with MVD,and the MTT、TTP was negatively correlated with MVD. VEGF positive group perfusion parameters BF、BV、 PMB were higher than VEGF negative expression group, positive group perfusion parameters MTT、TTP were shorter than negative group, the difference between the two groups were statistically significant(P<0.05).(3) The difference of PMB、BV in effective and ineffective group has a statistically significant(P<0.001) before neoadjuvant chemotherapy.The BF、 MTT、TTP was no significant difference(P> 0.05) in effective group and ineffective group before chemotherapy. Conclusion: Cervical cancer was a rich blood supply tumor, CT perfusion could evaluate cervical cancer angiogenesis in vivoimaging and provide evidence to predict sensitivity to neoadjuvant chemotherapy. |
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