| Objective: To explore the correlation between serum 25-hydroxyvitamin D level and early renal damage in patients with type 2 diabetes mellitus.Method: Retrospective study was performed in 291 inpatients diagnosed as type 2 diabetes mellitus from January 2014 to December 2014.According to the serum 25- hydroxyvitamin D levels,all the patients were divided as 25-hydroxyvitamin D deficiency(trial) group(n=182)(serum 25-hydroxyvitamin D<20ng/ml) and25-hydroxyvitamin Dsufficiency(control) group(n=109). The clinical data and laboratory test results of the patients were collected and analyzed so as to investigate the correlation between serum 25- hydroxyvitamin D levels and clinical indexes.Results: There were no significant differences between the two groups in gender,age, fasting blood glucose,triglyceride,Total choclesterol.(P>0.05). The BMI in the trial group(26.8 ± 03.76)kg was being higher than(25.54 ± 4.06)kg in the(’ontrol group(P<0.05). No significant differences between the two groups were found in creatinine,uric acid and cystatin C(P>0.05).But the value of 24-h urinary microalbumin was [23.88±46.26] 24h/mg in the trial group,being significantly higher than[6.48±12.04]24h/mg in the control group. The value of 24-h proteinuria was[23.88±46.26] mg in the trail group,being significantly higher than [6.48±12.04] mg in the conrol group(P<0.05). The multiple linear regression analysis showed 25-hydroxyvitamin D level was negatively correlated with 24h- microalbumininurine(r=-0.262,P<0.001) and 24-h proteinuria(r=-0.596,P<0.001). The multiple linear regression analysis showed 25-hydroxyvitamin D level was positively related to HDL(r=-0.169,P=0.004)and Esterase(r=-0.227, P<0.001),Conclusion: Serum 25-hydroxyvitamin D deficieney is associated with early renal damage in patients with type 2 diabetes mellitus,especially with impairment of the glomerulus. |
