Correlation Between 25 Hydroxyvitamin D Level And Skeletal Muscle Mass In Elderly Patients With Type 2 Diabetes

Objective:To investigate the relationship between serum 25 hydroxyvitamin D level and skeletal muscle mass in elderly patients with type 2 diabetes mellitus.Methods:73 elderly T2DM patients in the first Hospital of Shanxi Medical University from November 2021 to October 2022 were divided into three groups:normal group(25(OH)D≥75nmol/L)20 cases,deficiency group(75nmol/L>25(OH)D≥50nmol/L)21cases and deficiency group(25(OH)D<50nmol/L)32 cases.The general baseline data,biochemical indexes and body composition data measured by bioelectrical impedance analysis(DBA-550)were collected,and the relationship between serum 25(OH)D level and skeletal muscle mass was analyzed by multiple linear regression.Results:There was no significant difference in general baseline data among the three groups,and there was comparability among the three groups.There were significant differences in HOMA-IR,LDL-C,K~+,m A1b/CRE,skeletal muscle mass of left and right lower limbs,WHR,ASMI and RASM among the three groups(P<0.05).Spearman correlation analysis showed that the level of serum 25(OH)D was positively correlated with RASM(r=0.605,P<0.001).Multiple linear regression analysis was carried out with serum 25(OH)D,HOMA-IR,LDL-C,K+,m A1b/CRE,WHR as independent variables and RASM as dependent variables.The results showed that the regression model had significant statistical significance(F=20.831,P<0.001).The independent variable can explain 67.6%of the dependent variable and has a high degree of explanation.The results of significance test showed that the effect of serum 25(OH)D on RASM was statistically significant.Conclusion:Decreased vitamin D levels are an important risk factor for loss of skeletal muscle mass.Vitamin D supplements can be used as adjuvant therapy in patients with T2DM to prevent the occurrence of sarcopenia.