Efficacy Of Low-dose ⁹⁰Sr-⁹⁰Y Therapy Combined With Propranolol For The Treatment Of Superficial Infantile Hemangioma

Objective: This study is aimed to explore the clinical efficacy of low dose ⁹⁰Sr-⁹⁰Y application with propranolol for the treatment of infantile superficial hemangioma.Method: Superficial infantile hemangioma children of China Japan Union Hospital of Jilin University from September 2013 to January 2015 were chosen. The age range was 1-6 months. Children didn’t have any heart, lung, liver and other organ diseases. There was no any history of treatment, such as laser, surgery. Children were randomized to four different treatment methods group. Group A was treated with conventional dose ⁹⁰Sr-⁹⁰Y therapy; a course of radiation dose was 15-20 Gy. Group B was treated with propranolol and the therapeutic dose was 1.5mg/kg. Group C was treated with low dose ⁹⁰Sr-⁹⁰Y therapy; a course of radiation dose was 5-10 Gy. Group D was treated with low dose of ⁹⁰Sr-⁹⁰Y application and propranolol therapy; the dose was as above. Evaluation criteria for the curative effect of hemangioma: Cure: the skin color returned to normal or the local part of the skin was only left with little trace; Improvement: Hemangioma area became narrow and the color turned pale; Invalidity: there was a growth trend or no significant changes in hemangioma. [Note:（improvement + cure = effectiveness）]. The relative data were analyzed by Chi Square Test.Results: The general data of age, sex, position and size of hemangioma between four groups were no significant difference（P>0.05）. After two months treatment, the cure rate and effective rate of group A is 69.7% and 100%; group B is 12.3% and 83.6%; group C is 48.1% and 100%; group D is 48.8% and 100%. After four months treatment, the cure rate and effective rate of group A is 87.6% and 100%; group B is 23.3% and 89.0%; group C is 62.0% and 100%; and group D is 67.1% and 100%. After six months treatment, the cure rate and effective rate of group A is 93.3% and 100%; group B is 65.8% and 90.4%; group C is 75.9% and 100%; and group D is 92.7% and 100%. The cure rate between four groups was compared. After two months and four months treatment, the cure rate of group D and A was statistically significant（P<0.05）. However, after six months treatment, there was no statistically significant（P>0.05）. The cure rate of group D and B was statistically significant（P<0.05） at each stage of treatment. After two months and four months treatment, the cure rate of group D and C was no statistically significant（P>0.05）,but after six months treatment, there was statistically significant（P<0.05）.The incidence rate of adverse reaction of A, B, C and D groups were respectively 20.2%, 9.6%, 12.7 and 9.8%. Compared that of D group with that of A group, there was statistically significant difference（P<0.05）. Compared that of D group with that of B group and C group, there was no statistically significant difference（P>0.05）.Conclusion: Low dose of ⁹⁰Sr-⁹⁰Y application combined with propranolol for the treatment of superficial infantile hemangioma had a certain effect and fewer side effects and it is worthy of clinical application.