Analysis Of Ultrasonographic Characteristics In Medullary Thyroid Carcinoma

Objective: Through a retrospective analysis of the ultrasonographic(US) feature of thyroid medullary carcinoma(MTC) of 32 patients, and used Papillary thyroid carcinoma of 61 patients confirmed by pathological as the control group, to discuss the ultrasonographic characteristics of MTC.Methods: Selected 32 patients of Medullary Thyroid Carcinoma confirmed by pathology in the First and the Second Hospital of Jilin University from March 2006 to November 2014 who made thyroid ultrasound examination in preoperative in each hospital, 46 lesions totally. The control group is the Papillary thyroid carcinoma of 61 patients confirmed by pathological, 71 lesions totally In the preoperative ultrasound examination, two-dimensional gray-scale ultrasonography was applied to observed thyroid tumor location and quantity in parallel and perpendicularo to the long axis of the body.,then observed the size, shape(aspect ratio), border, internal echo, calcification, the type of calcification and the rear attenuation one by one further. Then applied the color doppler ultrasound(CDFI) to observe the case of the blood flow inside and around. Froze the images on the maximum diameter of the lesions, and recorded the sizes of the lesions.Using “regular” and “irregular” to discribe the forms of the lesions,while the ones A/T ratio >1 are special recording.Put the boundary conditions of the lesions into clear an unclear.Campared with the normal thyroid tissue,putting the lesions’ internal echos into hypoechoic,equal echo and hyperechoic. Divided the calcification of the lesions into calcified and non-calcified,then the calcification was divided into calcification and microcalcifications(the researcher of this study treated the ones that their diameter were <2mm as microcalcifications). Color Doppler flow imaging were divided into no flow(Ⅰ type), peripheral blood(Ⅱ type), internal blood flow(Ⅲ type) and internal, peripheral blood flow mixing(Ⅳ type). And scanned and recorded the number, size, shape, and internal echo of the cervical lymph nodes. By comparing the differences of ultrasonographic(US) feature of MTC, analyze the ultrasonographic characteristics in MTC. And according to the diagnostic situation of preoperative ultrasound examination, divided it into suspicious malignant, nature to be determined and suspicious benign. The findings of medullary and papillary carcinomas were compared using the chi-squared test.Results: Based on the number of lesions, location, two-dimensional ultrasound and color Doppler ultrasound analysis, the ultrasound mainly for medullary thyroid carcinoma is single, rather in the left and right lobe, solid hypoechoic mainly, equal echo of the minority, some lesions within the cystic; shape tending to still rules, boundary more clear; small part foci evident aspect ratio greater than 1; calcification; color Doppler ultrasound exploring blood flow. The ultrasound mainly for the control group of the Papillary thyroid carcinoma is single, rather in the left and right lobe, solid hypoechoic, some lesions within the cystic; Irregular, ill-defined; calcification, and micro calcification mainly;color Doppler ultrasound exploring blood flow. To compared the medullary with papillary carcinomas,the difference of The number of foci, shape and boundaries was with statistically significant(P <0.05),while the difference of The foci position, internal echo, cystic / solid, aspect ratio, calcification and colorful Doppler ultrasound had no statistically significant(P> 0.05). In the preoperative ultrasound examination, most lesions of medullary carcinoma and papillary carcinoma was diagnosed with malignant suspicious.Conclusions: MTC in ultrasound showed showed solid hypoechoic, with calcification, with the exploration of blood flow, which is generally the case in line with the ultrasonography of thyroid carcinoma. Most of medullary carcinoma were diagnosed as possibly malignant in the preoperative ultrasound examination. To compare with papillary carcinoma, the Medullary thyroid carcinoma in ultrasound has certain features of the higher proportion of cases solitary, tumor boundaries and shape tending to show a clear boundary, shape still rules.