Correlation Between Autophagy-Related Genes Polymorphism And The Susceptibility To Lung Carcinoma In A Chinese Southwestern Population

Objective:Autophagy is closely linked to many of the fatal diseases such as cancer. ATG4A polymorphisms was associated with diseases such as ulcerative colitis, but whether there is a correlation with the tumor has not been reported.We hypothesized that the intron single nucleotide polymorphism (SNP) of rs807185 in ATG4A was associated with risk of lung cancer.Methods:In this case-control study,225 cases of lung cancer and 257 cases of healthy controls were included. The documents of all patients and blood samples were collected. SNP of rs807185 was genotyped by PCR-RFLP. Logistic regression was used to analyze the correlation between the SNP and the susceptibility to lung cancer.Results:By binary logistic regression analysis adjusted for confounding factors such as age, sex, smoking history and alcohol consumption, compared with the wild T allele, the variant A allele of rs807185 in ATG4A was associated with a decreased risk of lung cancer [adjusted OR (95% CI)=0.466 (0.339-0.639), P<0.001]. Rs807185 locus carrying AA genotype has a slightly decreased possibility of lung carcinoma than TT/AT genotype, especially in the male group (P<0.001, OR (95% CI)=0.357 (0.288-0.612) and smoking group (P<0.001, OR (95% CI)=0.278 (0.152-0.510).Conclusion:The variant A allele of rs807185 in ATG4A is significantly associated with the decreased risk of lung cancer in a Southwestern Chinese population, especially in the male and smoking groups.