The Establishment Of Thromboelastography Reference Rangs In Pregnant Women

Objectives:l.To establish TEG and traditional coagulation tests reference intervals for healthy term pregnant women.2.To correlate Thromboelastography variables to reference intervals of standard laboratory analyses.Methods:Blood samples were collected from 183 healthy in term pregnant women.The following analyses were performed:time until start of clotting (TEG1-R), time until 20-mm clot firmness,(TEG1-K), angle of clotting (TEG1-a), maximum amplitude (TEG1-MA), and lysis after 30minutes (TEG1-LY30),coagulation index(CI), activated partial thromboplastin time(APTT), prothrombin time(PT), fibrinogen(FBN), International Normalized Ratio(INR),and platelet count(PLT).The reference intervals were established based on them.Results:1.95% reference intervals of traditional coagulation tests: PLT:169.83-185.46×109/L,INR:0.81-1.04, PT:11.20-13.60s,APTT:27.20-37.58, FBN:4.78-5.03g/L.95% reference intervals of TEG:R:2.40-9.50 min,K:0.80-2.86min,a:56.10-85.64°,MA:45.24-79.60mm,LY30:(-1.68)-9.08%, CI:(-4.00)-6.20.2.There were no or weak correlations between TEG variables and laboratory analysesConclusion:TEG parameters in pregnant women were beyond the "Normal" reference ranges provided by the manufacturer of the device,and the conventional diagnostic threshold is not suitable for the pregnant women.Specific reference intervals for TEG and traditional coagulation tests were established in this study,and they proved values for trigger intervention during pregnancy...