Relationship Of Serum 25-(OH) D Levels And Body Fat Distribution In Patients With Type 2 Diabetes

Objective:To investigate the relationship of serum 25-(OH) D levels and body fat distribution in patients with type 2 diabetes mellitus.Methods:We screened patients hospitalized in our department with type 2 diabetes mellitus from March 2014 to October 2014, including 62 cases of post-menopausal women and 24 cases of men over the age of 50 years old. Meanwhile, we measured their basic clinical information、 biochemical parameters、serum 25-(OH) D、body fat composition and other parameters. The 86 cases were divided into different groups by serum 25-(OH) D levels which were desperately named the severe shortage of group (25 cases)、the insufficient group (44 cases) and the lack of group (17 cases),then we compared the differences among the groups. Pearson correlation coefficients were applied in analyzing the correlations between the different body fat indexes, and stepwise multiple linear regression was involved in analyzing the relationship of biochemical parameters、serum 25-(OH) D and body fat indexes.Results:Compared with the lack of group, the VAT/SAT of the severe shortage one was higher (P<0.05), the BM1 of the insufficient group increased (P<0.05). We found that the level of VAT/SAT was related to theA/G、TF%/LF%、TFM/LFM(P<0.05). The BM was related to the BF%、A/G、TF%/LF%、TFM/LFM(P<0.05). Step wise multiple linear regression showed the level of 25-(OH) D was significantly associated with VAT/SAT in postmenopausal women (P<0.01).Conclusion:The 25-(OH) D levels of patients with type 2 diabetes mellitus affect body fat distribution, and the influences in postmenopausal women were more pronounced.