Expression Of Programmed Cell Death 5 In Endometrial Carcinoma And Its Significance

Objective:This study was designed to investigate the expression level of PDCD5 in endometrial carcinoma (EC), and speculate on its potential functions in the pathogenesis of EC.Method:60 fresh EC tissues determined endometrial adenocarcinoma, were obtained from patients who underwent endometrial carcinoma resection in the Department of Gynecology, Affiliated Hospital of Binzhou Medical University from May 2012 to February 2013. At the same time,28 endometrial atypical hyperplasia tissues via hysterectomy, and 40 normal proliferative endometrium via curettage were randomly selected. The expression of PDCD5, was detected by Real-time quantitative PCR and S-P immunohistochemical technique. The association with clinicopathologic factors was also analyzed. In the process of research, we were in full compliance with the ethical standards of the Ethics Committee of Affiliated Hospital of Binzhou Medical University.Results:The expression level of PDCD5 progressively decreased from the normal to the carcinoma, P≤0.05. To a certain degree, the expression of PDCD5 protein was positively correlated with TNM stage, histological grade, depth of myometrial invasion, and lymphatic metastasis,P≤0.05.Conclusion:The results of Realtime PCR and immunohistochemical test suggested that PDCD5 expression was significantly low in EC. Furthermore, the expression of PDCD5 protein was positively correlated with TNM stage, histological grade, depth of myometrial invasion, and lymphatic metastasis, but had no relation to age. PDCD5 might become a potential molecular marker of early diagnosis.