Relationship Between Visceral Fat Area And The Degree Of Coronary Artery Lesions In Patients With Normal Weight After PCI

Objective: Obesity is one of the main risk factors affecting coronary atherosclerotic heart disease. Recently, with the development of living quality and the change of working manner, the occurrence rate of obesity has increased greatly than before. Thus, the relationship between obesity and coronary heart disease has been the study focus. BMI is one of the most common indexes to determine whether the crowd are obese or not, Recent research found that in some certain ranges, with the increase of BMI, however, the incidence rate of insulin resistance and coronary heart disease and its death rate are lower than those with low BMI, which is called “obesity paradox”. The study indicated that it might be related with the viscera fat areas of obesity patients and the distribution of lean body mass index. This research aimed to study the relationship of visceral fat area to the degree of coronary artery lesions in patients after PCI with different BMI,provided the reference for the intervention of risk factors, the judgment of disease condition and rehabilitation in patients with coronary heart disease.Methods:Eight hundred and eighty-eight patients hospitalized in the diagnosis and treatment center of cardiovascular diseases of the first hospital of jilin university during January 2015 to December 2015 were collected who were diagnosed as coronary heart disease by the coronary angiography and were performed the viscera fat areas estimation. There are 674 males and 214 females in the age of 18-85 and the average age of 59.32 ± 9.56. Those patients with BMI measured ≥ 25kg/m2 were defined as the overweight group, with the total number of 474 cases, Those patients with BMI measured < 25kg/m2 were defined as the not overweight group,with the total number of 411 cases and performed the viscera fat areas estimation simultaneously. Those with VFA ≥100cm2 were defined as the non-abdomen type of obesity group,with the total number of 347 cases. Those with VFA <100cm2were defined as the abdomen type of obesity group,the number of these cases was 541. Combined with overweight the crowd is divided into four subgroups,the cases of OB(-)VF(-) groupn was 351,0B(-)VF(+) group was 60,0B(+)VF(-)group was 190,0B(+)VF(+)group was 287.The basic clinical data, biochemical indicators, and information about coronary artery intervention operation of patients on admission were collected and the genisi integration was calculated according to the results of coronary angiography.Results : Approximately 6.7% of patients after PCI had a body mass index(BMI)<25kg/m2 and a visceral fat area(VFA)≥100cm2(OB(-)VA(+)).OB(-)VA(+) patients had higher genisi Gensini scores than those with BMI≥25 kg/m2 and VFA≥100 cm2, those with BMI≥25 kg/m2 and VFA<100 cm2, and those with BMI<25 kg/m2 and VFA<100 cm2,The average age of OB(-)VA(+) patients was also older than the other three groups.In multivariate linear regression analysis, OB(-)VA(+) remained independently associated with the degree of coronary artery lesions(standardized β7.810, p=0.033)。Conclusion: This study provides evidence for the degree of corona ry artery lesions in OB(-)VA(+) patients who were diagnosed with Acute coronary syndrome after PCI; the mixed function of Increase d visceral adipose tissue and decreased muscle mass in patients can be part explained "obesity paradox’’ 。...