The Assessment Of Functional Dyspepsia With Cine-MR

Objective:To explore the value of Cine-MRfor assessment of the gastric and duodenum peristaltic and motility of functional dyspepsia. Method:25 patients with functional dyspepsia were selected according to the diagnostic criteria of Rome III of functional gastrointestinal disorders(FGIDs)as case group and 25 cases of healthy volunteers who had been screened out in clinic were used as normal control group. After fasting for 8h was performed in right lateral and supine position. Using 1.5TGEHDx MR coronal, oblique coronal and axial sequences of gastric and duodenal descending part with Cine-MR. The images of 5 and 15 min afterdrinking mannitol(concentration 2.5%) were collected and sent to MR AW4.4 workstation.By recording the frequency of contractions of the stomach and duodenum, measuring and calculatingthe percentage occlusion of gastric contraction(PGC), gastric motility index(GMI) and thepercentage occlusion of duodenum contraction(PDC) to reflect the gastric and duodenum peristaltic and motility of functional dyspepsia between difference patients and healthy volunteers. All data were statistically analyzed using SPSS19.0 software. Result:After drinking mannitol, the oblique coronal 、coronal and axialscan of all objects can clearly display the anatomical structure and peristaltic wave descending part of gastric and duodenum.1. After drinking mannitol 5 min, the gastric contraction frequency in case group was(2-3times/ min),was lower than these in normal control group(3-4times / min); After drinking 5 and 15 min of mannitol the peristaltic wave frequencies in case group was(1-2times/min) and((0-1times/ min)respectively,were lower than those in normal control group(2-3times /min) and(1-2times /min).2. After drinking mannitol 5min, by calculating the PDC、PGC、GMI were(38.07% ± 3.23)、(44.67% ± 11.08)、(10.49 ± 3.16) respectivelyin case group, were significantly lower than those in normal control group(67.92% ± 3.41)( 57.41% ± 9.83),(18.47 ± 5.92), P <0.001.3.After drinkingmannitol 15 min, PDC in normal control groupwas(33.86 ± 5.74) was significantly lower than in 5min(67.92 ± 3.41) P <0.001; but the PDCin normal control group and the case group(33.86 ± 5.74 VS 33.39 ± 6.99) have no significant difference P> 0.05; by calculating the PGC and GMI in case groupswere(35.86 ± 10.52)、(26.31 ± 3.42) respectively, were lower than innormalcontrol group(46.09 ± 9.23)、(30.51 ± 5.31), P <0.001. Conclusion:1. The gastrointestinal peristalsis and motility in FD and healthy people exist difference, comprehensive comparative analysis of multiple parameters, this study suggests that patients with functional dyspepsia mainly performance asthe percentage occlusion of gastric contraction(PGC), the percentage occlusion of duodenum contraction(PDC) and gastric motility index(GMI) were lower than healthy people.2. MR cine imaging techniques may be preliminary quantitative assessment of postprandial gastric and duodenum peristaltic and motility of functional dyspepsia, on this basis, we can use Cine-MR imaging techniques to further research thediagnosisfor functional gastrointestinal disorders.