| Objective:To observe the treatment of Tangshenkangyin on patients’ clinical symptoms and its effect on TCM syndrome score、TCM syndrome and serum level of MCP-1 of early diabetic nephropathy with deficiency of Qi and Yin with blood stasis type,evaluating the efficacy and safety of Tangshenkangyin.Methods:80 cases were randomly divided into control group and treatment group,each of 40 cases,two groups were treated with basic treatment of diabetes,the treatment group was treated with Tangshenkangyin for 8 weeks. Before and after the treatment,the urinary albumin excretion rate (UAER)^ serum MCP-1 level and TCM syndrome of the treatment group and the control group were observed and compared.Results:1.The comparasion of total efficiency of the treatment of early diabetic nephropathy of the control group and the treatment group with Tangshenkangyin treatment were respectively 25% and 73.7%, the curative effect of the control group and treatment group was statistically significant (P<0.01),treatment group curative effect is obviously superior to the control group.2.The total effective rate of improvement of TCM syndrome of the treatment group was 78.9%,the total effective rate of improvement of TCM syndrome of the control group was 20.0%, the significant difference of two groups compared, was statistically significant (P< 0.01), the improvement of the effect on TCM syndrome score of treatment group is obviously superior to the control group.3.There was no significant difference (P>0.05) between the UAER of before and after the treatment of control group. The UAER of treatment group after treatment than before was statistically significant (P<0.01);compared with the control group,the UAER after treatment was statistically significant(P<0.01).The treatment group in reducing the efficacy of UAER was obviously superior to the control group.4.Compared with the MCP-1 of control group before and after treatment,there was no significant difference(P>0.05). The serum level of MCP-1 after treatment than before treatment of treatment group were statistically significant(P<0.01);compared with the control group, the serum level of MCP-1 after treatment than before treatment of treatment group were statistically significant(P<0.01). The curative effect of the treatment group was significantly better than that of the control group in reducing the serum MCP-1.5.There was no significant adverse reactions were found in the two groups.Conclusion:1.Tangshenkangyin can significantly reduce the level of UAER in patients with early stage of diabetic nephropathy, it shows that Tangshenkangyin has a significant effect on reducing urinary protein.2.Tangshenkangyin can significantly reduce the TCM syndrome score of early diabetic nephropathy in patients,which can significantly improve that Tangshenkangyin has a significant effect on reducing TCM syndrome.3.Tangshenkangyin can significantly improve the TCM clinical symptoms in patients of early diabetic nephropathy with deficiency of Qi and Yin deficiency with blood stasis type with fatigue, thirst polydipsia, nocturia, five be perturbed are,and the heat, numbness of limbs, the curative effect is remarkable.4.Tangshenkangyin can significantly reduce the level of serum MCP-1 in patients of early diabetic nephropathy, which indicates that the Tangshenkangyin has a significant effect on reducing the serum MCP-1 level. The results showed that the effect of Tangshenkangyin can reduce the body’s inflammatory response. |
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