Study Of Corneal Sensation In Patients With Type Ⅱ Diabetes

Objective:To study the relationship between corneal sensation, age, disease duration, and glycemic control in diabetic patients.Methods:Randomly selected 92 cases (184 eyes) in Gulou Hospital Endocrinology Department between August 2012 and December 2012 as diabetic group. Patient’s diabetic duration, glycemic control, diabetic neurological symptoms, corneal sensitivity was measured. The measured value was studied between corneal sensitivity and other factors. At the same time,92 cases (184 eyes) cataract patients without diabetes, glaucoma or other eye diseases in ophthalmology department were collected as control group, including 50 males (100 eyes) and 42 females (84 eyes). Their age ranged from 40 to 80 years, mean age 71.93±9.6 years old.Results:Corneal sensitivity measured value of the diabetic group was significantly decreased compared with the control group, and diabetic peripheral neuropathy in long duration group (72%,18/25) was significantly higher than the short-course group (30%,6/30). In corneal sensation statistical, long duration group corneal sensation loss (3.73± 1.30) was more serious than the short-term group (4.84±1.36), and the difference was statistically significant (P<0.001); In glycemic control classification, the corneal sensitivity measured values in poor glucose control group (5.00±1.17) and good blood glucose control group (5.09± 1.05) did not differ significantly, and the proportion of diabetic peripheral neuropathy incidence in non-performing group (38%,31/81) and in glycemic control and good blood glucose control group (45%,5/11) also showed no significant difference (P> 0.1); In diabetic peripheral neuropathy classification, corneal sensitivity measured values of diabetic peripheral neuropathy group (4.26±0.37) was less than in diabetic patients without neuropathy group (5.36±0.36). Grouped according to the corneal sensitivity measured values, corneal peripheral neuropathy incidence of normal group (16%,6/38) was much lower than the corneal sensation reduced group (56%,30/54), corneal sensitivity measured value associated with age also showed significant difference (P< 0.001).Conclusion:Compared with the control group, the corneal sensation of diabetic patients decreased more seriously, indicating that diabetes affect the sensory function of the corneal nerves. The incidence of diabetic peripheral neuropathy in diabetic patients and corneal measurement value are closely related, indicating that decreased corneal sensation may be a manifestation of diabetic peripheral neuropathy.