| Objective: This subject was to study the clinical efficacy of the Chinese herbal compound named Fu Gan-chun 6(FGC-6) in treating middle-late stage primary liver cancer. Treatment group was given traditional Chinese medicine compound of FGC-6, while contrast group was given the conventional treatment. By observing symptoms,signs and the related test indicators of the two groups patients before and after treatment,we evaluated the clinical efficacy of FGC-6 in treating middle-late stage primary liver cancer. And explore the effective mechanism from the point of view of traditional Chinese medicine.Methods: Clinical research collected 94 patients who were conform to the requirements of the diagnosis in the middle-late stage primary liver cancer patients from December 2012 to December 2014,coming to our hospital, then divided the 94 patients into two groups randomly: treatment group(TG) of 54 patients and control groups(CG) of 40 patients. The treatment group would applicate the combined regimen of FGC-6 and internal conventional symptomatic treatment. And the control group applicated the internal conventional symptomatic treatment only. One month was one treatment course, and we would observe one or two course of treatment.Observed the two groups of patients the clinical symptoms, signs, li ver function, AFP, etc, before and after treatment. And to make clinical evaluation according to Response Evaluation Criteria. At the same time,observed the change of blood and urine routine, ECG, renal function a nd so on during the treatment to ensure the safety of patients.After observation data was collected, the statistical software was us ed to analyze and sum up, and the measurement data used sx ? to des cribe the statistical data, when the variance was consistent with normaldistribution, used t-test between groups, and when the variance was not homogeneous or not accorded with normal distribution, used Variance A nalysis. The statistical description of count data used frequency(constitu ent ratio),2X-test was used in comparison between groups. The results showed that the results were not statistically significant when P>0.05,and the results were statistically significant when P<0.05.Results: FGC-6 has good effect on relieving clinical symptoms,improving life quality and prolonging life.1 Comparison of the total effectThe total effective rate of the treatment group was 94.4%, apparently higher than the control group 62.5. The difference was statistically significant,P<0.01. The clinical effect of the two groups were different. The treatment group is better than the control group, which shows that the clinical effect of integrated Chinese and Western medicine treatment is good.2 Comparison of TCM symptom classifying quantization tableThe symptoms of two groups after treatment were improved. The symptoms integral Difference of control group was obvious, P<0.05, and the difference of treatment group before and after cimparison had more highly statistically significant, P<0.01. Symptoms integral differential of treatment group havd more advantages compared with control group, P< 0.05.3 Comparison of clinical curative effect of TCM SyndromeCompared the efficient rate of clinical syndrome curative effect of the two groups, the treatment group was better than that in control group, and there was statistically significant, P<0.05.4 Comparison of Karnofsky scoreThe integral of two groups before treatment is no statistical difference,P>0.05, comparable. KPS score of the two groups after treatment was improved than before, and the difference was statistically significant, P<0.05.KPS score of treatment group after treatment was improved obviously,superior to control group, P<0.05.5 Comparison of liver functionTwo groups of patients after treatment, ALT, AST, TBIL, ALB, AFP was all decreased than before, and differences were statistically significant,P<0.01. The value of ALT, AST, TBIL, ALB, AFP of treatment group after treatment was better than the that in control group, and the difference was statistically significant, P<0.05.6 Comparison of tumor indexes-AFPTwo groups of AFP significantly decreased after treatment, P<0.05.Compared with control group, treatment group has a certain difference in antitumor, P<0.05.7 Comparison of tumor’s objective curative effectThere were no cases of CR, PR, after treatment in the two groups of patients, and the effective rate was 0. The stability rate of treatment group after treatment was 59.26%, close to 55% in the control group. There was no statistical difference between the two groups, P>0.05.Conclusion: The results of the study showed that FGC-6 in relieving clinical symptoms, anti-tumor liver, and improving quality of life has better efficacy. FGC-6 combined with internal conventional symptomatic treatment in treatment of advanced liver cancer has better clinical efficacy than the simple use of internal conventional symptomatic treatment. It’s worthy for further clinical treatment, and it provides a new therapeutic approach and ideas.to treat advanced primary liver cancer. |
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