| Objective To assess the effects of inhaled corticosteroids on growth velocity in children with asthma.Methods We searched the Cochrane Airways Group Specialised Register of trials (CAGR), which is derived from systematic searches of bibliographic databases including CENTRAL, MEDLINE, EMBASE, CINAHL, AMED and PsycINFO. We also searched Wan Fang Chinese periodical Database and VIP Chinese periodical Database from the establishment of the database to October 2014. Articles which are parallel-group randomised controlled trials comparing daily use of ICS, delivered by any type of inhalation device, versus placebo or non-steroidal drugs in children up to 18 years of age with persistent asthma are selected. RevMan 5.2 software was used for data analysis.Results A total of 18 randomized control trials were included. Meta analysis showed that inhaled corticosteroids for 6-8 months,1 year significantly slowing down growth velocity in children with asthma (MD=-0.77,-0.55, respectively, P<0.00001). Inhaled corticosteroids for 2 years had no significant inhibition on growth velocity in children with asthma (MD=-0.30, P=0.74).Conclusions This systematic review showed that ICS therapy had temporarily inhibition on growth velocity in children with asthma, the peak inhibition happened within half a year, its inhibitory effect decreased with time. |
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