The Influence Of Inhaled Corticosteroids On Distribution Of Throat Floro In Children With Bronchial Asthma

Objective: To explore the effects of inhaled corticosteroids (ICS) on distribution of throat flora in children with bronchial asthma.Methods: The author chose randomly sixty healthy children as the control group and one hundred and sixty children with asthma in acute period before ICS therapy as the experimental group. The experimental group were treated with ICS therapy and then eighty-nine children of this group were followed up for 3 months ,sixty-eight for 6 months and sixty for 12 months. The ICS in the study was budesonide with the trade name as Pulmicort. We adopted swab from the pharynges respectively, inoculated it in agar plate, isolated the bacteria, and evaluated the distribution and variation of the microbial population in pharyngeal portion. The data collected were analyzed qualitatively.Results:①Bacteria could be detected in all the samples collected from children with asthma in acute period untreated, which were mainly non-β-hemolytic streptococcus and gram negative coccobacteria. Gram negative bacilli, Streptococcus pneumoniae and mycetes are less.②There were no significent differences (P＞0.05) between the distribution of throat flora in children with asthma in acute period and in children of good health.③The distribution of throat flora in children with asthma has not changed significantly 3, 6 and 12 months after children inhaled corticosteroids(P＞0.05). There was no obvious differences between that of control group and of experimental group.④There were no significent changes on distribution of throat flora among children with asthma treated with ICS after 3, 6 and 12 months (P＞0.05).⑤Three strains of mycetes were detected in the experimental group, and one strain in children with asthma treated with ICS for 6 months group.Conclusion:①There were no significent changes in the distribution of throat flora between the control group and the experimental group.. The throat microecology has not signiflcent changed.②Inhaled corticosteroids have no obvious effect in throat flora in children with asthma after being used for a short term and for 12 months, which suggested that inhaled corticosteroids (ICS) was a secure way in bronchial asthma treatment.③Dynamic monitoring of throat flora while the inhaled corticosteroids (ICS) are used is of clinical significance.