The Recent Advances The Research Progress Of Klotho Gene And Osteoporosis

The klotho gene is associated with aging, recent studies have shown that klotho participate in the occurrence and development of the osteoporosis. Many studies have confirmed that the mice of klotho gene defected make the aging skin, muscle atrophy, vascular calcification, osteoporosis, cognition impairment to speed up the aging process. Mass osteoporosis is primarily a characterized by bone mass and bone microstructure damage, increase osteopsathyrosis and systemic bone disease prone to fracture. Osteoporosis has a strong genetic background. Several studies have suggested klotho gene polymorphisms are associated with osteoporosis between the different races. The current exploration have found that single nucleotide polymorphisms of KL gene associated with bone mineral density, including KL G-395A,C1818T,F352V. Above is the study of genetic polymorphism in different race, gender, physical conditions of the conclusion. For nearly 16 years study, KL genes go through a variety of ways to participate in osteoporosis occurrence and development. KL, first as a FGFR1 c (Ⅲc) auxiliary factors, involved in FGF23 signal transduction process and adjust the secretion of parathyroid hormone. Secondly, KL may interfere with insulin and insulin-like growth factor 1 intracellular signal transduction; Thirdly, KL can act as a glycosidase because of its high similarity with other members of the glycosidase family, Combined with TRPV5 sugar-based and activate TRPV5 ion channels, regulate calcium, phosphorus absorption in the kidney and bone. The gene from the molecular level, and signaling pathways involved in the regulation of bone metabolism, By regulating the associated with bone metabolism of calcium, phosphorus, and active vitamin D3 involved in bone formation and bone resorption. This article reviews the evidence of the linkage between gene polymorphism of klotho, calcium-phosphorus metabolism, bone turnover and osteoporosis.