Non-Hdl-C For Risk Of Cardiovascular Disease In Newly Diagnosed Type 2 Diabetic Patients:a Correlation Study

Objective:To explore the association of non-high-density lipoprotein-cholesterol (non-HDL-C) with cardiovascular risk among patients with newly diagnosed type 2 diabetes mellitus (T2DM).Methods:The Framingham risk scores (FRS) for estimating the 10-year risk of cardiovascular disease (CVD) were evaluated among 352 patients in our hospital with newly diagnosed type 2 diabetes. The clinical data and biomedical analysis were collected. On the basis of FRS, the patients recruited were divided into high-risk group (FRS>20%,64 cases) and non-high-risk group (FRS<20%,288 cases). The differences of non-HDL-c and traditional CVD risk factors were compared between the two groups. The correlations of FRS with traditional CVD risk factors and non-HDL-c were assessed by bivariate correlation analysis. The association between non-HDL-c and high-risk FRS were evaluated by logistic regression. The predictive value of non-HDL-c for high-risk FRS was analyzed by ROC curve.Results:There were significantly differences in sex, age, history of smoking, systolic blood pressure, diastolic blood pressure, creatinine, LDL-c, HDL-c, TG and non-HDL-c between the two groups. No difference in HbA1c and TC. FRS was positively correlated with men, age, history of smoking, systolic blood pressure, diastolic blood pressure, creatinine, LDL-c, TG and non-HDL-c; while FRS was negatively correlated with HDL-c, but uncorrelated with HbAlc and TC. After adjustment with other confounding factors, Logistic regression showed that non-HDL-c was an independent risk factor for high-risk FRS (OR 2.550,95%CI 1.018-6.388, P=0.046). The AUC of the ROC analysis showed that non-HDL-c was of predictive value for high-risk FRS, better than traditional CVD risk factor-LDL-c (AUC 0.788 vs.0.735).Conclusions:Among patients with newly diagnosed T2DM, non-HDL-c was an independent risk factor for high-risk FRS, and might probably be able to identify the population at high risk of CVD events, which might be better than the traditional CVD risk factor- LDL-c.