The Significance Of Serum NSE And S-100β In Children With Severe Hand-foot-mouth Disease

Objectiv:To explore the relationship between serum neuron-specific enolase(NSE) and sangtec-100β(S-100β) with brain damage in children with hand-foot-mouth disease(HFMD).Method:Children with HFMD consecutively admitted to Quanzhou Children’s Hospital from March 2014 to August 2014 were included in this study. Diagnosis criteria was based on the 《Guideline of diagnosis and treatment of hand-foot-mouth disease(2010 edition)》published by Ministry of Health of the People’s Republic China. Patients were divided into critical group, severe group and ordinary group according to the clinical symptoms and signs, additional 20 healthy children were severed as control group. In the acute phase of illness(i.e, within 24 hours after admission), cerebrospinal fluid cytological and biochemical characteristics were determined and serum NSE and S-100β levels were measured by electrochemical immune luminescence method. Baseline data including age, sex, brain MRI, white blood cell count(WBC), blood glucose, alanine aminotransferase(ALT), and serum creatinine(SCr) were meanwhile recorded.Result: 1. There were no statistically significant differences between the four groups in age, sex distribution, WBC, ALT, and SCr, while the blood glucose in the critical group was significantly higher than those in other three groups.2. The serum NSE levels in the critical and severe group were significantly higher than those in the ordinary and control group(P<0.05), with NSE in the critical group further increased significantly when compared with severe group(P<0.05), while there was no marked difference between the ordinary and control group(P>0.05).3. The serum S-100β levels in the critical and severe group were significantly higher than those in the ordinary and control group(P<0.05), with S-100β in the critical group further increased significantly when compared with severe group(P<0.05), while there was no marked difference between the ordinary and control group(P>0.05).4. Patient in the critical group showed obvious brain injury in MRI scan. The serum NSE and S-100β levels were positively associated with the severity of hand-foot-mouth disease complicated with encephalitis and brain injury.Conclusion: The serum NSE and S-100β levels were significantly increased in the critical HFMD patients, which may reflect central nerve system impairment and predict poor prognosis.