The Correlation Between Cerebral Microbleeds And Impaired Kidney Function

Objective:Cerebral microbleeds is hemorrhagic lesions of the tiny blood vessels displayed on brain magnetic resonance imaging, CMBs are small perivascular haemosiderin-deposits within macrophages in the brain after blood leakage from pathologically fragile small vessels mainly affected by a variety of risk factors that damage nerve unit and blood-brain barrier.Leukoaraiosis with lacunar infarction and dilated perivascular spaces joint belongs to cerebral small vessel disease.CMBs is associated with many diseases, particularly it is of potential importance that the lesions are closely associated with spontaneous ICH and predict future occurrence or recurrence of ICH. Therefore, it is necessary to further study of risk factors with CMBs and the correlation with other diseases and prognosis.Recently,cerebral small vessel diseases such as lacunar infarcts and leukoaraiosis were reported as being associated with impaired kidney function.These findings highlighted the importance of kidney disease as a possible marker of cerebral small vessel pathology. As another radiologic manifestation of cerebral small vessel disease, the presence of cerebral microbleeds might also be associated with impaired kidney function. There is only a few studies in our country, this article will discuss the correlation between cerebral microbleeds and impaired kidney function and it’s risk factors,It’s possibility provided a basis for early recognition of cerebral microbleeds.Methods:A total of 184 patients with ischemic stroke between 30~80 years old who were consecutively admitted to Military General Hospital of The People’s Liberation Army between March 2013 and March 2014, All patients were performed brain MRI(includinggeneral sequencing and susceptibility-weighted imaging), According to the brain MRI magnetic sensitive weighted imaging(SWI) in the presence of the CMB is divided into CMBs group of 60 cases and no CMBs group 124 cases.We collected demographic,clinical, laboratory data, calculated Ccr, and did statistical comparison between two groups.Multiariable Logistic regression to determine the CMBs risk factors, finally,analysis of the correlation between impaired kidney function and CMBs distribution.Results:1.Univariate analysis showed that age[( 63.05±9.73) vt.( 58.25±10.40) year old],male(65% vt. 49.2%),the incidence of leukoaraiosis(73.3% vt. 47.6%) and plasma level of homocysteine [(20.30±7.69)vt.(16.24±5.91)μmol/L] were higher in CMBs group than no CMBs group,and the level of Ccr [(89.45±10.25)vt.(106.06±5.91)ml/(min1.73m2)] was lower in CMBs group than no CMBs group, there was statistically significant(P<0.05). there were no significant differences in smoking, drinking, lipid,diabetes, antiplatelet and statin therapy among the two groups(P>0.05).2.Multivariate logistic regression analysis showed that age(OR=1.103, 95%CI:1.024~1.989, P=0.028)、LA(OR=3.121, 95%CI:1.310~7.436, P=0.010)、impaired kidney function(OR=1.890, 95%CI: 1.358 ~3.076, P<0.001) were independent risk factors for ischemic stroke patients with CMBs.3.Analysis of the relationship between distribution of CMBs and impaired kidney function found that renal abnormalities were more common in patients with deep CMBs,there was statistically significant(χ2=12.195,P=0.002).Conclusion:Age、leukoaraiosis and impaired kidney function were the independent risk factors for ischemic stroke with CMBs. Impaired kidney function in patients with ischemic stroke are more likely to occur deep CMBs.Key words : Cerebral microbleeds; Ischemic stroke; Cerebral small vessel disease;...