The Influence Of That Using Anisodamine To Reduce The Possibility Of The Tourniquet Complication In Patients Undergoing Lower Extremity Surgery

Objective:To evaluate the role of anisodamine on the ischemia-reperfusion injury and pain by the case of tourniquet inflation.Methods:Forty ASA I Or II patients, aged 18-68, whose average time of tourniquet inflation(89.48±10.834) minutes, scheduled for unilateral lower extremity surgery, were divided into 2 groups, each group of 20 people:anisodamine group(group A) got iv anisodamine4 mg,and control group(group C) equal volume of normal saline.The spinal anesthesia was performed at the L3-4 interspace and the elbow in the middle of venous was placed for sampling. 1.Record blood pressure and heart rate four times when tourniquet was inflating(T1),tourniquet had inflated 45minute(T2), 1 minute(T3)before tourniquet deflation and 1 minute(T4)after tourniquet deflation. 2.Venous blood samples were collected immediately before tourniquet inflation(T0), 5 minute(T5) and 30 minutes(T6) after tourniquet deflation for measurement of plasma malondialdehyde(MDA).And the increasing amount of plasma MDA generated from tourniquet were figured out by them.3.During the tourniquet inflation,the occurrence of the tourniquet pain every group would be compared.Results:1. Compared with group C,T1 blood pressure in group A was high(P<0.05);T2-4blood pressure of two groups had no statistical significance(P>0.05); compared with C group, heart rate of group A at T1-4 had no statistically significant difference(P>0.05).2.Compared with group C,the increasing amount of plasma MDA generated from tourniquet in group A was decreased(P<0.05).3.The number who appeared the tourniquet pain in group A was lower than that in group C(P<0.05).Conclusion:1.The ischemia-reperfusion injury, one of tourniquet complication, could be attenuated by anisodamine in the way of inhibiting lipid peroxidation.2.Anisodamine could decrease the occurrence of the tourniquet pain within tourniquet inflation.