Influence Of Different Peritoneal Permeabilities On The Left Venticle Structure In Patients Who Underwent Continuous Ambulatory Peritoneal Dialysis

Objective:Influence of Different Peritoneal Permeabilities on The Left Venticle Structure in Patients Who Underwent Continuous Ambulatory Peritoneal Dialysis(CAPD).Methods:A total of 45 patients with CAPD select from the First Hospital of Shanxi Medical University in this study. Patient were divided into two groups through peritoneal equilibration test(PET): patients were high permeability(H) group, and low permeability(L)group. The selscted patients were followed up for 12 mouths, Hb, ALB, Potassium,Sodium, Calcium, Phosphorus, PTH, TC, TG, CRP were measured in all patients. Urine and peritoneal dialysis of patients with dialysis were collected and serum urea nitrogen(BUN), creatinine(SCr) and glucose were measured to calculate residual renal function(RRF) and the total urea kinetics(KT/V) of patients.Interventricular septum thickness(IVST), left ventricular diastolic diameter(LVDd), left ventricular posterior wall thickness(LVPWT) were measured by color Doppler echocardiography, and caculate left ventricular mass index(LVMI) according to the Reichek formula.Results:1.THE LVMI in allthe peritoneal patients correlated positively with CRP, peritoneal permeabilities(r=0.328 、 0.427, P<0.05), inversely with Hb, ALB, RRF, KT/V, BMI(r=-0.423、-0.383、-0.316、-0.317,P<0.05);2.Compared with L group, Hb[(95.00±11.42)g/L vs(112.25±8.39)g/L, P<0.001],ALB[(30.68±3.78)g/L vs(40.09±4.35)g/L, P<0.001]、RRF[(1.17±0.59)ml/min vs( 3.41±1.23) ml/min, P<0.001] 、 KT/V[( 1.85±0.47 vs( 2.32±0.83), P=0.035] was decreased, CRP[( 4.53±3.72) mg/d L vs( 1.45±0.85) mg/d L, P<0.001] 、LVMI[(147.75±25.33)g/m2vs(110.31±30.41)g/m2, P<0.001] was increased in H group.Conclusions:The Left ventricular hypertrophy in the high peritoneal transport status is a high risk.The Left ventricular hypertrophy maybe related with malnutrition, microinflammatory,inadequate dialysis and RRF.Further studies are required us determine whether the adverse prognosis of high transporters be improved by various therapeutic strategies.