Association Study Between Neuropeptide S Receptor Gene And Obsessive Compulsive Disorder In Chinese Han Population

Objective: To investigate the association between neuropeptide S receptor gene polymorphism and obsessive-compulsive disorder in a Chinese Han population.Methods: We assessed and analysised two single nucleotide polymorphisms-rs324981 and rs9655357 selected from neuropeptide S receptor gene from 400 patients with obsessive compulsive disorder according diagnostic criteria of The Diagnostic and Statistical Manual of Mental Disorders-IV and 459 healthy controls. We used Haploview 4.2 version to carry on hardy-weinberg equilibrium test, one site association analysis, linkage disequilibrium analysis and two loci haplotype analysis. Further stratified analysis according different gender, onset age and symptom dimention explored the association between neuropeptide S receptor gene and patients with subtypes of obsessive-compulsive disorder.Results: The genotype frequency distribution of rs9655357(CC, CG, GG) were significant different between late-onset obsessive-compulsive disorder patients and healthy controls(χ2 = 6.34,df = 2,p = 0.042), and genotype frequency of CC + GG in late-onset obsessive-compulsive disorder patients was significantly higher than that of healthy controls(χ2 = 6.274,p = 0.013). Genotype polymorphism of rs9655357 was associated with late onset obsessive-compulsive disorder patients. rs324981 and rs9655357 in male patients with obsessive-compulsive disorder were in completely linkage disequilibrium(D’=1.00, r2 = 0.36), and the T-C haplotype frequencies of rs324981-rs9655357 in male patients with obsessive-compulsive disorder was significantly higher than that of males in healthy controls(0.270 vs 0.216,χ2 = 4.117,p = 0.042). Locus rs324981-rs9655357 T-C haplotype was associated with male patients with obsessive-compulsive disorder.Conclusions: Our research demonstrates that the neuropeptide S receptor gene polymorphism is associated with obsessive-compulsive disorder in Chinese Han Population. Neuropeptide S system may be as a potiental important target for the study of obsessive-compulsive disorder in future.