Magnetic Resonance Spectrum Imaging Study On Frontal Cortex,Basal Ganglia And Thalamus In Patients With Bipolar Depressive Disorder And Their Healthy Unaffected Siblings

Objectives: To explore the Bipolar disorder and the genetic endophenotypes of metabolites in Frontal cortex, Basal ganglia and Thalamus, by using Magnetic resonance spectroscopy(MRS) to compare the differences of biochemical metabolites in Frontal cortex, Basal ganglia and Thalamus, among Bipolar depressive disorder(BDD) patients, Healthy unaffected siblings(SIB)and Healthy controls(HC). Methods: Potential objects of the study will be structurally clinically recruited by M.I.N.I,and diagnosed by DSM-IV. Objects of the study went through scale evaluation, general physical examination, and blood tests. GE 3.0T Discovery MRI was used to do the MRS scan on frontal cortex, basal ganglia and thalamus under resting state, while collecting data of N-acetylasparte(NAA), Cholinecompounds(Cho), Myo-inositol(m I), Lactic acid(Lac), and Creatine(Cr) in both sides of those three spots. 17 BDD patients, 14 SIB, and 14 HC were selected after recruiting, examinations, and scans. Data were recorded and analyzed by SPSS 13.0 statistical software. Results: 1、 Levels of NAA/Cr in right Frontal cortex were higher in HC, compared to BDDpatients and SIB(Fright =2.419,Pright =0.000); 2、 Levels of NAA/Cr in left Frontal cortex were higher in HC and SIB, compared toBDD patients(Fleft=3.839, Pleft=0.029); 3、 Levels of Lac/Cr in left Frontal cortex were higher in SIB and BDD patients,compared to HC(F=4.797, P=0.013); 4、 Levels of NAA/Cr in left Basal ganglia were lower in BDD patients and SIB,compared to HC(F=3.973,P=0.026); 5、 Levels of Lac/Cr in left Frontal cortex were positively correlated to HAMD24 inBDD patients(r=0.590,P=0.013); 6、 Ages of BDD patients were positively correlated to the levels of Lac/Cr in their rightThalamus(r=0.526,P=0.034); 7、 Episode times of BDD patients and their left Thalamus m I/Cr level demonstrated anegative correlation(r=-0.572,P=0.016); 8、 BDI patients showed a lower NAA/Cr level in right Basal ganglia than the BDIIpatients(t=-3.026, P=0.004). Conclusion: 1、Under resting state, SIB showed a decrease of NAA and an increase of Lac in left Basal ganglia and left Frontal cortex. Such changes could be involved in heredity related, and can be considered as the endophenotype of BDD. 2、BDD patients exhibited more neuron dysfunctions in left Basal ganglia and bilateral Frontal cortex. 3、BDI patients had more neuron dysfunctions than BDII patients in Basal ganglia.