Early Diagnostic Value Of The Modified AEEG And Critical Illness Scores In Neonates At Risk Of Brain Injury

Objective:To investigate the early diagnostic value of modified amplitude integrated electroencephalogram(a EEG) score, newborn critical cases score(NCIS) and neonatal acute physiology perinatal supplement-II(SNAPPE-II) score in neonates at risk of brain injury.Methods:The clinical data of 119 term neonates who were at risk of brain injury are retrospectively analyzed. The scores for modified a EEG, NCIS and SNAPPE-II were evaluated within the first 12 post-natal hours. The score differences and relevance between the non-brain-injury group and brain-injury group were compared. The predictive accuracy of these parameters in brain injury was expressed as area under the curve(AUC) of receiver operating characteristic curve(ROC). In addition, ROC was used to predict the optimal value of neonatal brain injury.Results:1. Among 119 neonates evaluated, 65 cases(54.6%) had brain injury.2. The modified a EEG and NCIS scores in brain-injury group(8.8 and 89.6repectively) were lower than in non-brain-injury group(11.2 and 104.7 respectively)(both P ? 0.001), but SNAPPE-II score in brain-injury group was significantly higher than in non-brain-injury group(28.9 vs 5.3)(P ? 0.001).3. Among 119 term neonates evaluated, the modified a EEG and NCIS scores were positively correlated(r = 0.716, P ? 0.001), SNAPPE-II score was negatively correlated with the modified a EEG and NCIS score(r =- 0.748, P ? 0.001 and r =-0.821, P ? 0.001).4. Measuring the scores as a predictor of brain injury, the best predictor values were 9.5, 95 and 22 respectively.Conclusions:There was correlation between the modified a EEG score, NCIS score and SNAPPE-II score. The above three score systems can be used as tools of brain function monitoring in perinatal newborns at risk of brain injury which contribute to a great significance in the early diagnosis of brain injury.