| Objective and significance: hypertension is one of the most common disease that seriously endanger people’s health. At present, there are lots of reports showing that some important organs, such as the brain, the heart, the kidney, all of which can be damaged by hypertension and finally lead to threatening patients’ life. Ambulatory arterial stiffness indices(AASI) is a kind of dynamic blood pressure monitored for 24 hours, which is also a new index calculated according to the data from the monitor. The main objective of this study is to find the correlation between AASI and renal damage in Primary Hypertension patients.Methods: all the patients selected with primary hypertension are diagnosed to conform with the version 2010 "Prevention Guide on Chinese Hypertension", and according to inclusion criteria and exclusion criteria, 192 cases who were diagnosed with primary hypertension are selected from March, 2013 to February, 2015 in Department of Cardiology of Affiliated Hospital of Yan’an University outpatient. The ambulatory blood pressure of patients is measured for 24 hours and the patient’s AASI are calculated. According to the quartiles, AASI were divided into four groups: group I <0.53(n = 49);0.53 ≤group II < 0.60(n = 51); 0.60 ≤ group III <0.69(n = 48);Group IV ≥ 0.69(n = 44).It is also necessary to text serum cystatin C(Cys C) and serum creatinine(Scr), calculate the endogenous creatinine clearance rate(Ccr), and then put the estimated value of both the Cys C and Scr into the corresponding estimating equation e GFR to calculate the Cys C-e GFR and(CKD-EPI)-e GFR. Using Pearson correlation and stepwise regression of multiple linear analyzes the correlation between AASI and renal damage in Primary Hypertension patients. Results:1. There are no statistical significance in heart rate and BMI among the four groups(P>0.05), while some statistical significance in age(P<0.05), which presents that the age follows the trend of increase with the increase of AASI; there are some statistical significance in 24 h PP among the four groups(P<0.05), which presents that 24 h PP follows the trend of gradual increase with the increase of AASI.2. There are some statistical significance when comparing the Scr index in Group II with that in group I, also the same result when comparing group III with group I, as well as group IV compared with group I, group II and group III(P<0.05); there are some statistical significance when comparing the Cys C index in group II with that in group I, also the same result when comparing group III with group I and group II, as well as group IV compared with group I,group II and group III(P<0.05); there are some statistical significance when comparing the Ccr index in group II with that in group I, also the same result when comparing group III with group I, as well as group IV compared with group I, group II and group III(P<0.05); there are some statistical significance when comparing the Cys C-e GFR index in group II with that in group I, also the same result when comparing group III with group I and group II, as well as group IV compared with group I, group II and group III(P<0.05); there are some statistical significance when comparing(CKD-EPI)-e GFR index in group II with group I, and the same result when comparing group III with group I, as well as group IV compared with group I, group II and group III,(P<0.05).3. After correcting the factor of age, the analysis on partial correlation is: AASI is positively correlated with Cys C(r=0.637), but negatively correlated with Ccr, Cys C-e GFR and(CKD-EPI)-e GFR(R:-0.361,-0.698,-0.331).4. The analysis on the results of the stepwise regression model of multiple linear shows that: the regression equation of cystatin C and AASI is: Cys C=0.658+2.101×AASI; the regression equation of Ccr and AASI, age, as well as BMI is: Ccr=120.002-39.895 × AASI-0.897 × age-1.212 × BMI; the regression equation of Cys C-e GFR and AASI is: Cys C-e GFR=121.599-157.978 × AASI; the regression equation of(CKD-EPI)-e GFR and AASI, age is:(CKD-EPI)-e GFR=130.001-35.001×AASI-0.602×age(P <0.05).Conclusion:1. The age and 24 h PP follow the trend of increase with the increase of AASI, which presents that the age may be the factors promoting primary hypertension to affect renal damage, and also suggests that AASI can be used as a new index to reflect the arterial compliance.2.AASI is showed a linear correlation with all the indexes of renal damage, which can be the predictors of renal damage caused by primary hypertension.3.Cystatin C and the estimated glomerular filtration rate Cys C-e GFR which is based on cystatin C are more sensitive than the other indicators to evaluate the degree of early renal damage.4. Obesity may also becomes the factor promoting primary hypertension to affect renal damage. |
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