Study Of The Pathological Changes Of Lung Tissue In Rats Living In Moderate Elevation Under Different Time

Objective To sdudy the effect of hypobaric hopoxia on the lung tissue structure in Rats by observing the thickness of pulmanary alveolus wall, emphysema changes, the thickness of alveolar capillary wall and the condition of lymphocytes infltration surrounding arteriole, at an altitude of 2,260 meters at different times.Methods 48 Wistar rats were randomly divided into six groups with 8 in each group: the control group(at an altitude of 1,500), 1 day at moderate altitude group, 3 days at moderate altitude group, 7 days at moderate altitude group, 15 days at moderate altitude group, 30 days group at moderate altitude. After the excisional biopsy was stained by htoxylineosi(HE), we observed the changes of the thickness of pulmanary alveolus wall, emphysema changes, the thickness of alveolar capillary wall and lymphocytes infltration surrounding small blood vessels.Results We found(1) compared the lung tissue structure of rats at moderate altitude with that at low altitude, it suggests that hypoxia will cause lung tisse structure destruction;(2) when rats staying longer time in hyopbaric chamber, the number of rats with broad pulmanary alveolus wall, thicker arteriole wall, lymphocytes infltration surrounding small blood vessels, compensating emphysema will increase gradually;(3) when the ratio increases to a certain degree, lung tissue will produce hypoxia adaptation and the incidence of compensating emphysema will decrease gradually.Conclusion These results suggest that as time goes by, the hypoxia environment at moderate altitude will bring more damage to lung tissue structure. After hypoxia adaptation, the lunge tissue of the body will be tolerate to hypoxia, which will reduce the damage to the lung tissue structure to a certain extent.