Simulation Study Of Pathological Changes Of Lung Tissue In Rats Living In High Altitude Under Different Time

Objectives: To sdudy the effect of hypobaric hopoxia on the lung tissue structure in Rats by observing the thickness of pulmanary alveolus wall, emphysema changes, the thickness of alveolar capillary wall and the condition of lymphocytes infltration surrounding arteriole, at an altitude of 5,000 meters at different times.Methods: 48 Wistar rats were randomly divided into six groups with 8 in each group: the control group(at an altitude of 1,500), 1 day at high altitude group, 3 days at high altitude group, 7 days at high altitude group, 15 days at high altitude group, 30 days at high altitude group. After the excisional biopsy was stained by HE stain, we observed the changes of the thickness of pulmanary alveolus wall, the thickness of small pulmanary artery,lymphocytes infltration surrounding small blood vessels and emphysema changes. Results:(1)The comparison of high altitude group and low altitude group suggests that the lung tissue structures were broken under the low oxygen environment.(2) The long duration in the lung tissue structure will make the number of rats with pulmanary alveolus wall, the thickness of small pulmanary artery, lymphocytes infltration surrounding small blood vessels and emphysema changes increase.(3) when the ratio increases reached to certain extent, the lung structure will experience hypoxia adaptation. As a result, the incidence of thicker arteriole wall,lymphocytes infltration surrounding small blood vessels and emphysema changes will decrease gradually. Conclusion: These results suggest that as time goes by, the hypoxia environment at high altitude will bring more damage to lung tissue structure. When lung tissue experienced hypoxia adaptation, the lung tissue structure’s resistance ability of low oxygen environment became higher. As a result, the damage of the lung tissue structure will become less seriously to some extent.